发明申请
US20120208844A1 SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF
有权
增加P53活性的替代品PIPERIDIN及其用途
- 专利标题： SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF
- 专利标题（中）： 增加P53活性的替代品PIPERIDIN及其用途
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申请号： US13501685申请日： 2010-10-05
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公开(公告)号： US20120208844A1公开(公告)日： 2012-08-16
- 发明人: Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
- 申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
- 国际申请： PCT/US2010/051403 WO 20101005
- 主分类号： A61K31/4545
- IPC分类号： A61K31/4545 ; A61P35/02 ; A61P35/00 ; C07D409/14 ; C07D401/14
摘要：
The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
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