Invention Application
US20120289684A1 METHODS OF TREATING INFLAMMATION USING SOLUBLE IL-17RA/RC FUSION PROTEINS
审中-公开
使用可溶性IL-17RA / RC融合蛋白治疗炎症的方法
- Patent Title: METHODS OF TREATING INFLAMMATION USING SOLUBLE IL-17RA/RC FUSION PROTEINS
- Patent Title (中): 使用可溶性IL-17RA / RC融合蛋白治疗炎症的方法
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Application No.: US13487828Application Date: 2012-06-04
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Publication No.: US20120289684A1Publication Date: 2012-11-15
- Inventor: Steven D. Levin , Mark W. Rixon , Zeren Gao
- Applicant: Steven D. Levin , Mark W. Rixon , Zeren Gao
- Applicant Address: US WA Seattle
- Assignee: ZYMOGENETICS, INC.
- Current Assignee: ZYMOGENETICS, INC.
- Current Assignee Address: US WA Seattle
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/42
Abstract:
Disclosed are antagonists of IL-17A and IL-17F. The antagonists are based on soluble IL-17RA and IL-17RC fusion proteins, including hybrid soluble receptors comprising portions of both IL-17RC and IL-17RA (“IL-17RC/IL-17RA”). Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F. Also disclosed are methods of using such antagonists for treating disease, particularly inflammatory diseases mediated at least in part by IL-17A and/or IL-17F.
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