公开(公告)号：US11542327B2

公开(公告)日：2023-01-03

申请号：US16834607

申请日：2020-03-30

申请人： ZymoGenetics, Inc. ,  Merck Serono S/A

发明人： Kent Bondensgaard ,  Roland Beckmann

IPC分类号： A61K39/00 ,  C07K16/24 ,  C12N15/63 ,  C12N5/10

摘要： The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing, inhibiting, limiting, or reducing the proinflammatory or pro-pruritic effects of IL-31.

公开(公告)号：US20220002419A1

公开(公告)日：2022-01-06

申请号：US17483262

申请日：2021-09-23

申请人： ZYMOGENETICS, INC.

发明人： Zeren GAO ,  Steven D. LEVIN ,  Janine M. BILSBOROUGH ,  James W. West ,  Cameron S. BRANDT ,  Eric M. Chadwick

IPC分类号： C07K16/28 ,  G01N33/50 ,  A61K39/395 ,  C07K14/705 ,  C07K14/47 ,  C12Q1/66 ,  G01N33/569

摘要： The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.

公开(公告)号：US10000563B2

公开(公告)日：2018-06-19

申请号：US15208202

申请日：2016-07-12

申请人： ZymoGenetics, Inc.

发明人： Stephen R. Jaspers ,  Scott R. Presnell ,  Monica J. Huber

IPC分类号： A61K39/395 ,  C07K16/24 ,  G01N33/68 ,  C07K16/46 ,  A61K39/00

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N33/6869 ,  G01N2333/54 ,  Y10S530/809

摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, hybridomas that produce the antibodies, and methods of using the same in inflammation.

公开(公告)号：US20180155418A1

公开(公告)日：2018-06-07

申请号：US15429750

申请日：2017-02-10

申请人： ZymoGenetics, Inc.

发明人： Cindy A. Sprecher ,  Joseph L. Kuijper ,  Maria M. Dasovich ,  Francis J. Grant ,  Jane A. Gross ,  Angela K. Hammond

IPC分类号： C07K16/24 ,  C07K14/52 ,  A61K38/00 ,  C07K14/47

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K2317/24

摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：US09822177B2

公开(公告)日：2017-11-21

申请号：US15298911

申请日：2016-10-20

申请人： ZymoGenetics, Inc.

发明人： Anthony W. Siadak ,  Shirley A. Rene ,  Janine M. Bilsborough

IPC分类号： A61K39/395 ,  C07K16/24 ,  A61K39/00

CPC分类号： C07K16/244 ,  A61K47/60 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention provides the hybridomas that generate the monoclonal antibodies and the amino acid sequences of the variable regions of the monoclonal antibodies and chimeric antibodies comprising the amino acid sequences of the light and heavy chain variable regions.

公开(公告)号：US09663566B2

公开(公告)日：2017-05-30

申请号：US14109165

申请日：2013-12-17

申请人： ZymoGenetics, Inc.

发明人： Carl W Birks ,  Brian A Fox ,  Mark W Rixon ,  Jeff L Ellsworth

IPC分类号： C07K14/705 ,  C07K14/735 ,  C07K1/00 ,  A61K39/00 ,  A61K38/00

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/70535

摘要： Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid FcγR polypeptides.

公开(公告)号：US09156909B2

公开(公告)日：2015-10-13

申请号：US14031963

申请日：2013-09-19

申请人： ZymoGenetics, Inc.

发明人： Anthony W. Siadak ,  Janine Bilsborough ,  Shirley Rene

IPC分类号： C12N5/10 ,  C12N15/13 ,  C12N15/63 ,  C12N15/64 ,  C07K16/24 ,  A61K39/00

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S514/885 ,  Y10S514/886

摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies.

摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的延迟型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮红斑痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明进一步提供产生单克隆抗体的杂交瘤。

公开(公告)号：US08968732B2

公开(公告)日：2015-03-03

申请号：US14134278

申请日：2013-12-19

申请人： ZymoGenetics, Inc.

发明人： Yue Yao ,  Janine Bilsborough

IPC分类号： A61K39/395 ,  C07K16/24 ,  C07K14/54 ,  A61K38/17 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/244 ,  A61K38/1793 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/2866 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/76

摘要： Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.

摘要翻译： 使用拮抗剂IL-31用于通过抑制，预防，减少，最小化，限制或最小化神经元组织中的刺激来治疗炎症和疼痛。 这样的拮抗剂包括抗体及其片段，衍生物或变体。 症状如疼痛，刺痛，致敏，与神经病相关的痒症得到改善。

公开(公告)号：US20150037331A1

公开(公告)日：2015-02-05

申请号：US14498058

申请日：2014-09-26

申请人： ZymoGenetics, Inc.

发明人： Anthony W. Siadak ,  Shirley A. Rene

IPC分类号： C07K16/24 ,  A61K47/48

CPC分类号： C07K16/244 ,  A61K47/60 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention provides the hybridomas that generate the monoclonal antibodies and the amino acid sequences of the variable regions of the monoclonal antibodies and chimeric antibodies comprising the amino acid sequences of the light and heavy chain variable regions.

摘要翻译： 本发明涉及治疗瘙痒症的方法，包括但不限于接触性皮炎，特应性皮炎，药物诱导的延迟型皮肤过敏反应，毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，斑秃，白癜风，痤疮红斑痤疮， 腮腺炎，硬皮病，单纯疱疹病毒或其组合通过施用IL-31单克隆抗体。 本发明提供产生单克隆抗体的杂交瘤和单克隆抗体的可变区的氨基酸序列和包含轻链和重链可变区的氨基酸序列的嵌合抗体。

公开(公告)号：US08907068B2

公开(公告)日：2014-12-09

申请号：US12124946

申请日：2008-05-21

申请人： Wenfeng Xu ,  Wayne R. Kindsvogel ,  Zhi Chen ,  Steven D. Hughes ,  Yasmin A. Chandrasekher ,  Stacey R. Dillon ,  Joyce M. Lehner ,  Anthony W. Siadak ,  Pallavar V. Sivakumar ,  Margaret D. Moore

发明人： Wenfeng Xu ,  Wayne R. Kindsvogel ,  Zhi Chen ,  Steven D. Hughes ,  Yasmin A. Chandrasekher ,  Stacey R. Dillon ,  Joyce M. Lehner ,  Anthony W. Siadak ,  Pallavar V. Sivakumar ,  Margaret D. Moore

IPC分类号： C07K16/24 ,  A61K38/17 ,  A61K47/48 ,  C07K16/28 ,  C07K14/715 ,  C07K14/54 ,  A61K38/20 ,  A61K39/00

CPC分类号： C07K16/2866 ,  A61K38/1793 ,  A61K38/20 ,  A61K47/60 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/7155 ,  C07K16/244 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30

摘要： The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.

摘要翻译： 本发明涉及阻断IL-20多肽分子的活性。 IL-20是涉及炎症过程和人类疾病的细胞因子。 IL-20RA / IL-20RB是IL-20的常见受体。 本发明包括抗IL-20抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-20的方法。