发明申请
- 专利标题： Antibodies Reactive with B7-H3 and Uses Thereof
- 专利标题（中）： 抗B7-H3抗体及其用途
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申请号： US13463924申请日： 2012-05-04
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公开(公告)号： US20120294796A1公开(公告)日： 2012-11-22
- 发明人: Leslie S. Johnson , Ling Huang , Paul A. Moore , Deryk T. Loo , Francine Z. Chen
- 申请人： Leslie S. Johnson , Ling Huang , Paul A. Moore , Deryk T. Loo , Francine Z. Chen
- 申请人地址： US MD Rockville
- 专利权人： MACROGENICS, INC.
- 当前专利权人： MACROGENICS, INC.
- 当前专利权人地址： US MD Rockville
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/574 ; C12N5/10 ; C12N5/16 ; A61P35/02 ; C07K16/00 ; C07K16/18 ; C07H21/04 ; A61P35/00 ; A61K51/00 ; C12N15/63
摘要：
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
公开/授权文献
- US08802091B2 Antibodies reactive with B7-H3 and uses thereof 公开/授权日：2014-08-12
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