发明申请
- 专利标题: SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME
- 专利标题(中): 奥扎唑化合物的合成中间体及其制备方法
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申请号: US13574546申请日: 2011-01-28
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公开(公告)号: US20120302757A1公开(公告)日: 2012-11-29
- 发明人: Akihiro Yamamoto , Koichi Shinhama , Nobuhisa Fujita , Shinji Aki , Shin Ogasawara , Naoto Utsumi
- 申请人: Akihiro Yamamoto , Koichi Shinhama , Nobuhisa Fujita , Shinji Aki , Shin Ogasawara , Naoto Utsumi
- 申请人地址: JP Chiyoda-ku, Tokyo
- 专利权人: OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人: OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Chiyoda-ku, Tokyo
- 优先权: JP2010-019289 20100129
- 国际申请: PCT/JP2011/052307 WO 20110128
- 主分类号: C07D211/22
- IPC分类号: C07D211/22 ; C07D498/04 ; C07D211/58 ; C07D405/12
摘要:
An object of the present invention is to provide a method for producing an oxazole compound in a high yield.The object can be achieved by a compound represented by Formula (11): wherein R1 is a hydrogen atom or lower-alkyl group; R2 is a 1-piperidyl group substituted at the 4-position with a substituent selected from (A1a) a phenoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1b) a phenoxy-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkyl groups, (A1c) a phenyl-substituted lower-alkoxy lower-alkyl group substituted on the phenyl moiety with halogen, (A1d) a phenyl-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1e) an amino group substituted with a phenyl group substituted with one or more halogen-substituted lower-alkoxy groups, and a lower-alkyl group, and (A1f) a phenyl-substituted lower-alkoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups; n is an integer from 1 to 6; and X3 is an organic sulfonyloxy group.
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