公开(公告)号：US20120302757A1

公开(公告)日：2012-11-29

申请号：US13574546

申请日：2011-01-28

申请人： Akihiro Yamamoto ,  Koichi Shinhama ,  Nobuhisa Fujita ,  Shinji Aki ,  Shin Ogasawara ,  Naoto Utsumi

发明人： Akihiro Yamamoto ,  Koichi Shinhama ,  Nobuhisa Fujita ,  Shinji Aki ,  Shin Ogasawara ,  Naoto Utsumi

IPC分类号： C07D211/22 ,  C07D498/04 ,  C07D211/58 ,  C07D405/12

CPC分类号： C07D211/46 ,  C07D405/12 ,  C07D498/04

摘要： An object of the present invention is to provide a method for producing an oxazole compound in a high yield.The object can be achieved by a compound represented by Formula (11): wherein R1 is a hydrogen atom or lower-alkyl group; R2 is a 1-piperidyl group substituted at the 4-position with a substituent selected from (A1a) a phenoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1b) a phenoxy-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkyl groups, (A1c) a phenyl-substituted lower-alkoxy lower-alkyl group substituted on the phenyl moiety with halogen, (A1d) a phenyl-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1e) an amino group substituted with a phenyl group substituted with one or more halogen-substituted lower-alkoxy groups, and a lower-alkyl group, and (A1f) a phenyl-substituted lower-alkoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups; n is an integer from 1 to 6; and X3 is an organic sulfonyloxy group.

摘要翻译： 本发明的目的是提供以高产率制备恶唑化合物的方法。 该目的可以通过式（11）表示的化合物来实现：其中R1是氢原子或低级烷基; R2是在4-位被取代基取代的1-哌啶基，该取代基选自（A1a）苯基部分被一个或多个卤素取代的低级烷氧基取代的苯氧基，（A1b）苯氧基取代的低级烷氧基， 在苯基部分上被一个或多个卤素取代的低级烷基取代的烷基（A1c）在苯基部分被卤素取代的苯基取代的低级烷氧基低级烷基，（A1d）苯基取代的低级烷基， 在苯基部分被一个或多个卤素取代的低级烷氧基取代的烷基，（A1e）被被一个或多个卤素取代的低级烷氧基取代的苯基取代的氨基和低级烷基， 和（A1f）在苯基部分上被一个或多个卤素取代的低级烷氧基取代的苯基取代的低级烷氧基; n是1至6的整数; X3是有机磺酰氧基。

公开(公告)号：US08598358B2

公开(公告)日：2013-12-03

申请号：US13574546

申请日：2011-01-28

申请人： Akihiro Yamamoto ,  Koichi Shinhama ,  Nobuhisa Fujita ,  Shinji Aki ,  Shin Ogasawara ,  Naoto Utsumi

发明人： Akihiro Yamamoto ,  Koichi Shinhama ,  Nobuhisa Fujita ,  Shinji Aki ,  Shin Ogasawara ,  Naoto Utsumi

IPC分类号： C07D211/46 ,  C07D405/12 ,  C07D498/04

CPC分类号： C07D211/46 ,  C07D405/12 ,  C07D498/04

摘要： An object of the present invention is to provide a method for producing an oxazole compound in a high yield.The object can be achieved by a compound represented by Formula (11): wherein R1 is a hydrogen atom or lower-alkyl group; R2 is a 1-piperidyl group substituted at the 4-position with a substituent selected from (A1a) a phenoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1b) a phenoxy-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkyl groups, (A1c) a phenyl-substituted lower-alkoxy lower-alkyl group substituted on the phenyl moiety with halogen, (A1d) a phenyl-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1e) an amino group substituted with a phenyl group substituted with one or more halogen-substituted lower-alkoxy groups, and a lower-alkyl group, and (A1f) a phenyl-substituted lower-alkoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups; n is an integer from 1 to 6; and X3 is an organic sulfonyloxy group.

摘要翻译： 本发明的目的是提供以高产率制备恶唑化合物的方法。 该目的可以通过式（11）表示的化合物来实现：其中R1是氢原子或低级烷基; R2是在4-位被取代基取代的1-哌啶基，该取代基选自（A1a）苯基部分被一个或多个卤素取代的低级烷氧基取代的苯氧基，（A1b）苯氧基取代的低级烷氧基， 在苯基部分上被一个或多个卤素取代的低级烷基取代的烷基（A1c）在苯基部分被卤素取代的苯基取代的低级烷氧基低级烷基，（A1d）苯基取代的低级烷基， 在苯基部分被一个或多个卤素取代的低级烷氧基取代的烷基，（A1e）被被一个或多个卤素取代的低级烷氧基取代的苯基取代的氨基和低级烷基， 和（A1f）在苯基部分上被一个或多个卤素取代的低级烷氧基取代的苯基取代的低级烷氧基; n是1至6的整数; X3是有机磺酰氧基。

公开(公告)号：US20140187782A1

公开(公告)日：2014-07-03

申请号：US14235635

申请日：2012-07-27

申请人： Koichi Shinhama ,  Naoto Utsumi ,  Masahiro Sota ,  Shigeo Fujieda ,  Shin Ogasawara

发明人： Koichi Shinhama ,  Naoto Utsumi ,  Masahiro Sota ,  Shigeo Fujieda ,  Shin Ogasawara

IPC分类号： C07D409/12 ,  C07D333/54

CPC分类号： C07D409/12 ,  C07D333/54 ,  Y02P20/55

摘要： The present invention provides a method for producing a compound of Formula (4): wherein R1 is a hydrogen atom etc. by reacting a compound of Formula (2): wherein X1 is a leaving group, with a compound of Formula (3): wherein R1 is as defined above, in the presence of (a) a palladium compound and a tertiary phosphine or (b) a palladium carbene complex, in an inert solvent or without a solvent. The present invention can produce the compound of Formula (4), with high purity and high yield, and by a simple operation.

摘要翻译： 本发明提供式（4）的化合物的制备方法：其中，R 1为氢原子等，式（2）的化合物：其中X1为离去基团与式（3）的化合物反应： 其中R 1如上定义，在（a）钯化合物和叔膦或（b）钯卡宾络合物的存在下，在惰性溶剂中或不用溶剂存在下进行。 本发明可以通过简单的操作制备高纯度和高收率的式（4）化合物。

公开(公告)号：US09206169B2

公开(公告)日：2015-12-08

申请号：US14235635

申请日：2012-07-27

申请人： Koichi Shinhama ,  Naoto Utsumi ,  Masahiro Sota ,  Shigeo Fujieda ,  Shin Ogasawara

发明人： Koichi Shinhama ,  Naoto Utsumi ,  Masahiro Sota ,  Shigeo Fujieda ,  Shin Ogasawara

IPC分类号： C07D409/12 ,  C07D333/54

CPC分类号： C07D409/12 ,  C07D333/54 ,  Y02P20/55

摘要： The present invention provides a method for producing a compound of Formula (4): wherein R1 is a hydrogen atom etc. by reacting a compound of Formula (2): wherein X1 is a leaving group, with a compound of Formula (3): wherein R1 is as defined above, in the presence of (a) a palladium compound and a tertiary phosphine or (b) a palladium carbene complex, in an inert solvent or without a solvent. The present invention can produce the compound of Formula (4), with high purity and high yield, and by a simple operation.

摘要翻译： 本发明提供式（4）的化合物的制备方法：其中，R 1为氢原子等，式（2）的化合物：其中X1为离去基团与式（3）的化合物反应： 其中R 1如上定义，在（a）钯化合物和叔膦或（b）钯卡宾络合物的存在下，在惰性溶剂中或不用溶剂存在下进行。 本发明可以通过简单的操作制备高纯度和高收率的式（4）化合物。

公开(公告)号：US20110207842A1

公开(公告)日：2011-08-25

申请号：US13059779

申请日：2009-08-03

申请人： Shinji Kato ,  Shin Ogasawara

发明人： Shinji Kato ,  Shin Ogasawara

IPC分类号： C08F22/00

CPC分类号： C08J9/283 ,  B01J31/06 ,  B01J2231/46 ,  C08F290/145 ,  C08F299/024 ,  C08G18/603 ,  C08G18/6423 ,  C08G18/8116 ,  C08G2101/00 ,  C08J2201/024 ,  C08J2300/202 ,  C08L75/16 ,  C08F222/1006

摘要： The present invention relates to organic polymer porous materials, and in particular, to an organic polymer porous material that functions as a reusable insoluble solid catalyst and a method for producing the same. The organic polymer porous material of the present invention is characteristic in that the amount of immobilized bases is high and the specific surface area is large. The object has been achieved by an organic polymer porous material including a polymer (PA) obtained by polymerizing a polymerizable composition (A) containing a compound (a) obtained by reacting a dendrimer (a1) having at least an amino group as a reactive functional group or a polyethyleneimine (a2) having at least an amino group as a reactive functional group with a compound (a3) having a vinyl group and a group that can react with the reactive functional group.

摘要翻译： 本发明涉及有机聚合物多孔材料，特别涉及作为可重复使用的不溶性固体催化剂起作用的有机聚合物多孔体及其制造方法。 本发明的有机聚合物多孔体的特征在于固定化碱的量高，比表面积大。 该目的已经通过有机聚合物多孔材料来实现，所述有机聚合物多孔材料包括通过聚合含有通过使具有至少一个氨基的树枝状大分子（a1）作为反应性官能团的化合物（a）获得的可聚合组合物（A） 或具有至少具有氨基作为反应性官能团的聚乙烯亚胺（a2）与具有乙烯基的化合物（a3）和可与反应性官能团反应的基团。

公开(公告)号：US08097657B2

公开(公告)日：2012-01-17

申请号：US13059779

申请日：2009-08-03

申请人： Shinji Kato ,  Shin Ogasawara

发明人： Shinji Kato ,  Shin Ogasawara

IPC分类号： C08J9/28 ,  C08F299/02

CPC分类号： C08J9/283 ,  B01J31/06 ,  B01J2231/46 ,  C08F290/145 ,  C08F299/024 ,  C08G18/603 ,  C08G18/6423 ,  C08G18/8116 ,  C08G2101/00 ,  C08J2201/024 ,  C08J2300/202 ,  C08L75/16 ,  C08F222/1006

摘要： The present invention relates to organic polymer porous materials, and in particular, to an organic polymer porous material that functions as a reusable insoluble solid catalyst and a method for producing the same. The organic polymer porous material of the present invention is characteristic in that the amount of immobilized bases is high and the specific surface area is large. The object has been achieved by an organic polymer porous material including a polymer (PA) obtained by polymerizing a polymerizable composition (A) containing a compound (a) obtained by reacting a dendrimer (a1) having at least an amino group as a reactive functional group or a polyethyleneimine (a2) having at least an amino group as a reactive functional group with a compound (a3) having a vinyl group and a group that can react with the reactive functional group.

摘要翻译： 本发明涉及有机聚合物多孔材料，特别涉及作为可重复使用的不溶性固体催化剂起作用的有机聚合物多孔体及其制造方法。 本发明的有机聚合物多孔体的特征在于固定化碱的量高，比表面积大。 该目的已经通过有机聚合物多孔材料来实现，所述有机聚合物多孔材料包括通过聚合含有通过使具有至少一个氨基的树枝状大分子（a1）作为反应性官能团的化合物（a）获得的可聚合组合物（A） 或具有至少具有氨基作为反应性官能团的聚乙烯亚胺（a2）与具有乙烯基的化合物（a3）和可与反应性官能团反应的基团。