利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.025 秒)

    Synthetic intermediate of oxazole compound and method for producing the same
    1.
    发明授权
    Synthetic intermediate of oxazole compound and method for producing the same 有权
    恶唑化合物的合成中间体及其制造方法

    公开(公告)号：US08598358B2

    公开(公告)日：2013-12-03

    申请号：US13574546

    申请日：2011-01-28

    申请人： Akihiro Yamamoto ,  Koichi Shinhama ,  Nobuhisa Fujita ,  Shinji Aki ,  Shin Ogasawara ,  Naoto Utsumi

    发明人： Akihiro Yamamoto ,  Koichi Shinhama ,  Nobuhisa Fujita ,  Shinji Aki ,  Shin Ogasawara ,  Naoto Utsumi

    IPC分类号： C07D211/46 ,  C07D405/12 ,  C07D498/04

    CPC分类号： C07D211/46 ,  C07D405/12 ,  C07D498/04

    摘要： An object of the present invention is to provide a method for producing an oxazole compound in a high yield.The object can be achieved by a compound represented by Formula (11): wherein R1 is a hydrogen atom or lower-alkyl group; R2 is a 1-piperidyl group substituted at the 4-position with a substituent selected from (A1a) a phenoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1b) a phenoxy-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkyl groups, (A1c) a phenyl-substituted lower-alkoxy lower-alkyl group substituted on the phenyl moiety with halogen, (A1d) a phenyl-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1e) an amino group substituted with a phenyl group substituted with one or more halogen-substituted lower-alkoxy groups, and a lower-alkyl group, and (A1f) a phenyl-substituted lower-alkoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups; n is an integer from 1 to 6; and X3 is an organic sulfonyloxy group.

    摘要翻译： 本发明的目的是提供以高产率制备恶唑化合物的方法。 该目的可以通过式（11）表示的化合物来实现：其中R1是氢原子或低级烷基; R2是在4-位被取代基取代的1-哌啶基，该取代基选自（A1a）苯基部分被一个或多个卤素取代的低级烷氧基取代的苯氧基，（A1b）苯氧基取代的低级烷氧基， 在苯基部分上被一个或多个卤素取代的低级烷基取代的烷基（A1c）在苯基部分被卤素取代的苯基取代的低级烷氧基低级烷基，（A1d）苯基取代的低级烷基， 在苯基部分被一个或多个卤素取代的低级烷氧基取代的烷基，（A1e）被被一个或多个卤素取代的低级烷氧基取代的苯基取代的氨基和低级烷基， 和（A1f）在苯基部分上被一个或多个卤素取代的低级烷氧基取代的苯基取代的低级烷氧基; n是1至6的整数; X3是有机磺酰氧基。

    SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME
    2.
    发明申请
    SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME 有权
    奥扎唑化合物的合成中间体及其制备方法

    公开(公告)号：US20120302757A1

    公开(公告)日：2012-11-29

    申请号：US13574546

    申请日：2011-01-28

    申请人： Akihiro Yamamoto ,  Koichi Shinhama ,  Nobuhisa Fujita ,  Shinji Aki ,  Shin Ogasawara ,  Naoto Utsumi

    发明人： Akihiro Yamamoto ,  Koichi Shinhama ,  Nobuhisa Fujita ,  Shinji Aki ,  Shin Ogasawara ,  Naoto Utsumi

    IPC分类号： C07D211/22 ,  C07D498/04 ,  C07D211/58 ,  C07D405/12

    CPC分类号： C07D211/46 ,  C07D405/12 ,  C07D498/04

    摘要： An object of the present invention is to provide a method for producing an oxazole compound in a high yield.The object can be achieved by a compound represented by Formula (11): wherein R1 is a hydrogen atom or lower-alkyl group; R2 is a 1-piperidyl group substituted at the 4-position with a substituent selected from (A1a) a phenoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1b) a phenoxy-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkyl groups, (A1c) a phenyl-substituted lower-alkoxy lower-alkyl group substituted on the phenyl moiety with halogen, (A1d) a phenyl-substituted lower-alkyl group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups, (A1e) an amino group substituted with a phenyl group substituted with one or more halogen-substituted lower-alkoxy groups, and a lower-alkyl group, and (A1f) a phenyl-substituted lower-alkoxy group substituted on the phenyl moiety with one or more halogen-substituted lower-alkoxy groups; n is an integer from 1 to 6; and X3 is an organic sulfonyloxy group.

    摘要翻译： 本发明的目的是提供以高产率制备恶唑化合物的方法。 该目的可以通过式（11）表示的化合物来实现：其中R1是氢原子或低级烷基; R2是在4-位被取代基取代的1-哌啶基，该取代基选自（A1a）苯基部分被一个或多个卤素取代的低级烷氧基取代的苯氧基，（A1b）苯氧基取代的低级烷氧基， 在苯基部分上被一个或多个卤素取代的低级烷基取代的烷基（A1c）在苯基部分被卤素取代的苯基取代的低级烷氧基低级烷基，（A1d）苯基取代的低级烷基， 在苯基部分被一个或多个卤素取代的低级烷氧基取代的烷基，（A1e）被被一个或多个卤素取代的低级烷氧基取代的苯基取代的氨基和低级烷基， 和（A1f）在苯基部分上被一个或多个卤素取代的低级烷氧基取代的苯基取代的低级烷氧基; n是1至6的整数; X3是有机磺酰氧基。

    Amine salt of carbostyril derivative
    8.
    发明授权
    Amine salt of carbostyril derivative 有权
    喹诺酮衍生物的胺盐

    公开(公告)号：US08222276B2

    公开(公告)日：2012-07-17

    申请号：US12662610

    申请日：2010-04-26

    申请人： Yoshihiro Nishioka ,  Shinji Aki ,  Shigekazu Fujita ,  Yoshinao Onishi ,  Shun-ichiro Sumida

    发明人： Yoshihiro Nishioka ,  Shinji Aki ,  Shigekazu Fujita ,  Yoshinao Onishi ,  Shun-ichiro Sumida

    IPC分类号： A61K31/04 ,  C07D215/38

    CPC分类号： C07D215/227

    摘要： The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.

    摘要翻译： 本发明提供由式（1）表示的喹诺酮衍生物形成的喹诺酮衍生物的胺盐[其中R是卤素原子; 侧链的取代位置是喹诺酮骨架中的3-或4-位; 并且喹诺酮骨架的3-和4-位之间的键合是单键或双键]和胺; 本发明由于具有优异的水溶性和优异的药理作用而用作治疗各种疾病的药物，特别是作为水性制剂。

    Method of producing aminophenol compounds
    9.
    发明授权
    Method of producing aminophenol compounds 失效
    制备氨基苯酚化合物的方法

    公开(公告)号：US07750156B2

    公开(公告)日：2010-07-06

    申请号：US10593968

    申请日：2005-03-25

    申请人： Hiroshi Kiyokawa ,  Shinji Aki

    发明人： Hiroshi Kiyokawa ,  Shinji Aki

    IPC分类号： C07D241/04 ,  C07D401/00 ,  C07D211/40

    CPC分类号： C07D295/096 ,  C07C213/02 ,  C07C215/76 ,  C07C215/82

    摘要： The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity. The present invention provides a method of producing an aminophenol compound represented by the formula (1): (wherein each of R1 and R2, which may be the same or different, is a hydrogen atom, a substituted or unsubstituted lower alkyl group or the like; R1 and R2, taken together with the adjacent nitrogen atom, may form a 5- or 6-membered heterocycle with or without other intervening heteroatoms; the heterocycle may be substituted by 1 to 3 substituents selected from the group consisting of a hydroxyl group, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aryloxy group and the like; and the hydroxyl group in the formula (1) is substituted on the 2- or 4-position to the amino group on the phenyl ring), which comprises allowing a cyclohexanedione compound represented by the formula (2) to react with an amine compound represented by the formula (3) (wherein R1 and R2 are as defined above), under a neutral or basic condition.

    摘要翻译： 本发明提供了一种工业上有利的方法，通过简单和容易的方法以高产率和高纯度制备由式（1）表示的氨基苯酚化合物。 本发明提供一种由式（1）表示的氨基苯酚化合物的制造方法：（其中R 1和R 2可以相同或不同，为氢原子，取代或未取代的低级烷基等 ; R 1和R 2与相邻的氮原子一起可以与有或没有其它插入的杂原子形成5-或6-元杂环;该杂环可以被1至3个选自羟基， 取代或未取代的低级烷基，取代或未取代的芳基，取代或未取代的芳氧基等;式（1）中的羟基在2-或4-位被氨基取代， 苯环），其包括使式（2）表示的环己二酮化合物与式（3）表示的胺化合物（其中R 1和R 2如上所定义）在中性或碱性下反应 c条件。

    Process for producing carbostyril derivatives
    10.
    发明授权
    Process for producing carbostyril derivatives 有权
    喹诺酮衍生物的制备方法

    公开(公告)号：US07399864B2

    公开(公告)日：2008-07-15

    申请号：US10208738

    申请日：2002-08-01

    申请人： Shinji Aki ,  Muneaki Kurimura ,  Takao Nishi ,  Junichi Minamikawa ,  Michiaki Tominaga

    发明人： Shinji Aki ,  Muneaki Kurimura ,  Takao Nishi ,  Junichi Minamikawa ,  Michiaki Tominaga

    IPC分类号： C07D215/38

    CPC分类号： C07D401/12 ,  A61K31/4709

    摘要： The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high purity. The carbostyril derivatives (I) can be produced by reacting a carbostyril derivative (II) with a tetrazole derivative (III) in the presence of a phase transfer catalyst.

    摘要翻译： 本发明提供了以高产率和高纯度制备喹诺酮衍生物（I）的方法，已知其可用作药物如抗血栓形成剂，脑循环改进剂，抗炎剂，抗溃疡剂等。 喹诺酮衍生物（I）可以通过在相转移催化剂存在下使喹诺酮衍生物（II）与四唑衍生物（III）反应来制备。