发明申请
US20120309730A1 OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING
审中-公开
激活肝脏X受体信号和抑制HEDGEHOG信号的氧化酶
- 专利标题： OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING
- 专利标题（中）： 激活肝脏X受体信号和抑制HEDGEHOG信号的氧化酶
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申请号： US13579278申请日： 2011-02-16
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公开(公告)号： US20120309730A1公开(公告)日： 2012-12-06
- 发明人: Farhad Parhami , Michael Jung , Khanhlinh Nguyen , Dongwon Yoo , VIncente Meliton
- 申请人： Farhad Parhami , Michael Jung , Khanhlinh Nguyen , Dongwon Yoo , VIncente Meliton
- 申请人地址： US MD Baltimore US CA Oakland
- 专利权人： The Johns Hopkins University,The Regents of the University of California
- 当前专利权人： The Johns Hopkins University,The Regents of the University of California
- 当前专利权人地址： US MD Baltimore US CA Oakland
- 国际申请： PCT/US11/25064 WO 20110216
- 主分类号： A61K31/575
- IPC分类号： A61K31/575 ; C07J43/00 ; A61K31/58 ; C12N5/09 ; A61P35/04 ; A61P1/16 ; C12N5/071 ; C07J9/00 ; A61P35/00
摘要：
This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
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