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1.发明申请OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING 审中-公开激活肝脏X受体信号和抑制HEDGEHOG信号的氧化酶公开(公告)号：US20120309730A1
公开(公告)日：2012-12-06
申请号：US13579278
申请日：2011-02-16
IPC分类号： A61K31/575 , C07J43/00 , A61K31/58 , C12N5/09 , A61P35/04 , A61P1/16 , C12N5/071 , C07J9/00 , A61P35/00
CPC分类号： A61K31/575 , A61K31/56 , A61K31/569 , A61K31/58 , A61K45/06
摘要： This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
摘要翻译： 本发明涉及例如包含由式I或式II表示的氧固醇化合物的组合物，例如包含O 16，Oxy 22，Oxy 30，Oxy 31，Oxy 35，Oxy 37，Oxy 43，Oxy 44，Oxy 45或Oxy 47中的一种或多种。 化合物显示为抑制Hedgehog途径，并作为肝脏X受体（LXR）的激动剂。 还公开了使用本发明组合物抑制Hedgehog信号传导作用如细胞增殖的方法，包括治疗有需要的受试者，以及用于实施本发明方法的药物组合物和试剂盒。
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2.发明申请ROLE OF HEDGEHOG SIGNALING IN ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASE 审中-公开HEDGEHOG信号在ATHEROSCLEROSISIS和心血管疾病中的作用公开(公告)号：US20100112030A1
公开(公告)日：2010-05-06
申请号：US12531608
申请日：2008-03-17
申请人： Farhad Parhami , Michael E. Jung , Khanhlinh Nguyen , Dongwon Yoo
发明人： Farhad Parhami , Michael E. Jung , Khanhlinh Nguyen , Dongwon Yoo
CPC分类号： A61K31/575
摘要： The present invention provides methods and related compositions for treating or preventing cardiovascular diseases, including, e.g., atherosclerosis, using an oxysterol. In addition, the present invention provides novel methods and related compositions for treating or preventing cardiovascular diseases, including, e.g., atherosclerosis, using a hedgehog protein, or a biologically active fragment or variant thereof.
摘要翻译： 本发明提供了使用氧固醇治疗或预防心血管疾病（包括动脉粥样硬化）的方法和相关组合物。 此外，本发明提供用于治疗或预防心血管疾病的新方法和相关组合物，包括例如动脉粥样硬化，使用刺猬蛋白或其生物活性片段或变体。
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3.发明申请OXYSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING 有权用于激活HEDGEHOG信号，OSTEOINDUCTION，抗原成熟和WNT信号的氧化酶公开(公告)号：US20110008297A1
公开(公告)日：2011-01-13
申请号：US12745888
申请日：2008-12-03
申请人： Farhad Parhami , Michael E. Jung , Khanhlinh Nguyen , Dongwon Yoo , Woo-Kyun Kim
发明人： Farhad Parhami , Michael E. Jung , Khanhlinh Nguyen , Dongwon Yoo , Woo-Kyun Kim
IPC分类号： A61K35/12 , C07J9/00 , A61K31/575 , A61K38/29 , A61K33/16 , A61K38/30 , A61K38/18 , A61P3/04 , A61P5/18 , A61P19/10 , C12N5/00 , A61P9/10 , A61P17/14 , C07J33/00
CPC分类号： A61K31/575 , A61K45/06 , A61K2300/00
摘要： Synthetic oxysterols can be made and can be used for the treatment of bone disorders, obesity, cardiovascular disorders, and neurological disorders.
摘要翻译： 可以制备合成氧固醇，可用于治疗骨骼疾病，肥胖，心血管疾病和神经障碍。
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4.发明授权Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling 有权氧化固醇激活刺猬蛋白信号传导，骨诱导，抗脂肪生成和Wnt信号传导公开(公告)号：US09526737B2
公开(公告)日：2016-12-27
申请号：US12745888
申请日：2008-12-03
申请人： Farhad Parhami , Michael E. Jung , Khanhlinh Nguyen , Dongwon Yoo , Woo-Kyun Kim
发明人： Farhad Parhami , Michael E. Jung , Khanhlinh Nguyen , Dongwon Yoo , Woo-Kyun Kim
IPC分类号： A01N63/00 , A61K31/575 , A61K45/06
CPC分类号： A61K31/575 , A61K45/06 , A61K2300/00
摘要： Synthetic oxysterols can be made and can be used for the treatment of bone disorders, obesity, cardiovascular disorders, and neurological disorders.
摘要翻译： 可以制备合成氧固醇，可用于治疗骨骼疾病，肥胖，心血管疾病和神经障碍。
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5.发明申请公开(公告)号：US20100105645A1
公开(公告)日：2010-04-29
申请号：US12520281
申请日：2007-12-19
CPC分类号： A61K31/57 , C07J1/00 , G01N2333/70567 , G01N2500/00 , G01N2500/10
摘要： This invention relates to methods for using agents to inhibit peroxisome proliferator activated receptor expression.
摘要翻译： 本发明涉及使用试剂抑制过氧化物酶体增殖物激活受体表达的方法。
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公开(公告)号：US20100034781A1
公开(公告)日：2010-02-11
申请号：US12224430
申请日：2007-02-27
CPC分类号： C07J9/00
摘要： This invention relates, for example, to synthetic oxysterols. Also described are methods for using the compounds, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
摘要翻译： 本发明涉及例如合成氧固醇。 还描述了使用化合物的方法，包括治疗有需要的受试者，以及用于实施本发明方法的药物组合物和试剂盒。
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公开(公告)号：US09670244B2
公开(公告)日：2017-06-06
申请号：US12224430
申请日：2007-02-27
IPC分类号： A61K31/575 , C07J9/00
CPC分类号： C07J9/00
摘要： This invention relates, for example, to synthetic oxysterols. Also described are methods for using the compounds, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
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8.发明授权公开(公告)号：US08022052B2
公开(公告)日：2011-09-20
申请号：US12520281
申请日：2007-12-19
IPC分类号： A61K31/56
CPC分类号： A61K31/57 , C07J1/00 , G01N2333/70567 , G01N2500/00 , G01N2500/10
摘要： This invention relates to methods for using agents to inhibit peroxisome proliferator activated receptor expression.
摘要翻译： 本发明涉及使用试剂抑制过氧化物酶体增殖物激活受体表达的方法。
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9.发明申请Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins 有权用于通过与骨形态发生蛋白结合的氧固醇来增强骨形成的药剂和方法公开(公告)号：US20060251735A1
公开(公告)日：2006-11-09
申请号：US10569994
申请日：2004-08-30
申请人： Farhad Parhami
发明人： Farhad Parhami
CPC分类号： A61K31/56 , A61K31/22 , A61K31/59 , A61K31/66 , A61K33/06 , A61K38/1875 , C12N5/0654 , C12N2501/155 , C12N2501/999 , A61K2300/00
摘要： The present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and methods to treat patients to maintain bone mass, enhance bone formation and/orbone repair. Exemplary agents include oxysterols, alone or in combination with particular oxysterols, or other agents, such as bone morphogenic proteins, known to assist in bone formation. The invention further includes medicaments including oxysterols for the treatment of bone disorders and implants to facilitate bone repair.
摘要翻译： 本发明公开了用于诱导成骨细胞分化的药剂和方法，以及使用这些药剂和方法来治疗患者以维持骨量，增强骨形成和/或骨修复。 示例性试剂包括单独或与特定氧固醇组合的氧固醇，或已知有助于骨形成的其他试剂，例如骨形态发生蛋白。 本发明还包括药物，包括用于治疗骨骼疾病的氧固醇和促进骨修复的植入物。
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10.发明授权Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins 有权用于通过与骨形态发生蛋白结合的氧固醇来增强骨形成的药剂和方法公开(公告)号：US09532994B2
公开(公告)日：2017-01-03
申请号：US10569994
申请日：2004-08-30
申请人： Farhad Parhami
发明人： Farhad Parhami
CPC分类号： A61K31/56 , A61K31/22 , A61K31/59 , A61K31/66 , A61K33/06 , A61K38/1875 , C12N5/0654 , C12N2501/155 , C12N2501/999 , A61K2300/00
摘要： The present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and methods to treat patients to maintain bone mass, enhance bone formation and/or bone repair. Exemplary agents include oxysterols, alone or in combination with particular oxysterols, or other agents, such as bone morphogenic proteins, known to assist in bone formation. The invention further includes medicaments including oxysterols for the treatment of bone disorders and implants to facilitate bone repair.
摘要翻译： 本发明公开了用于诱导成骨细胞分化的药剂和方法，以及这些药物和方法用于治疗患者以维持骨量，增强骨形成和/或骨修复的用途。 示例性试剂包括单独或与特定氧固醇组合的氧固醇，或已知有助于骨形成的其他试剂，例如骨形态发生蛋白。 本发明还包括药物，包括用于治疗骨骼疾病的氧固醇和促进骨修复的植入物。
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