发明申请
![PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS](/docs/US/2012-12-20/US20120322791A1/abs.jpg.600x600.jpg)
- 专利标题： PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS
- 专利标题（中）： 吡咯并[1,5-a]吡嗪化合物作为mTOR抑制剂
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申请号： US13520274申请日： 2011-01-18
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公开(公告)号： US20120322791A1公开(公告)日： 2012-12-20
- 发明人: M. Arshad Siddiqui , Yang Nan , Mehul F. Patel , Panduranga Adulla P. Reddy , Umar Faruk Mansoor , Zhaoyang Meng , Lalanthi Dilrukshi Vitharana , Lianyun Zhao , Amit K. Mandal , Duan Liu , Shuyi Tang , Andrew McRiner , David B. Belanger , Patrick J. Curran , Chaoyang Dai , Angie R. Angeles , Liping Yang , Matthew Hersh Daniels
- 申请人： M. Arshad Siddiqui , Yang Nan , Mehul F. Patel , Panduranga Adulla P. Reddy , Umar Faruk Mansoor , Zhaoyang Meng , Lalanthi Dilrukshi Vitharana , Lianyun Zhao , Amit K. Mandal , Duan Liu , Shuyi Tang , Andrew McRiner , David B. Belanger , Patrick J. Curran , Chaoyang Dai , Angie R. Angeles , Liping Yang , Matthew Hersh Daniels
- 国际申请： PCT/US11/21534 WO 20110118
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61K31/5377 ; C07D487/08 ; A61K31/55 ; A61P35/00 ; C07D498/08 ; A61K31/5386 ; C07D513/08 ; A61K31/547 ; C07D491/147 ; C07D487/04 ; C07D471/08
![PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS](/abs-image/US/2012/12/20/US20120322791A1/abs.jpg.150x150.jpg)
摘要：
The present invention provides Pyrazolopyrimidine Compounds of Formula (I): wherein L, T, Z, U, V, W, R3, R6, R7, R8, and m are as defined herein, and pharmaceutically acceptable salts of such Pyrazolopyrimidine Compounds. The Pyrazolopyrimidine Compounds are useful in the treatment of cancer and other diseases or disorders wherein mTOR is deregulated.
公开/授权文献
- US09227971B2 Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors 公开/授权日：2016-01-05