- 专利标题： Inhibition of AXL Signaling in Anti-Metastatic Therapy
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申请号： US13554954申请日： 2012-07-20
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公开(公告)号： US20130017205A1公开(公告)日： 2013-01-17
- 发明人: Amato J. Giaccia , Erinn Bruno Rankin , Jennifer R. Cochran , Douglas Jones , Mihalis Kariolis , Katherine Fuh , Yu Miao
- 申请人： Amato J. Giaccia , Erinn Bruno Rankin , Jennifer R. Cochran , Douglas Jones , Mihalis Kariolis , Katherine Fuh , Yu Miao
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K16/28 ; A61K39/395 ; A61P35/00 ; C12Q1/68 ; C12N5/10 ; C12N5/12 ; C12N1/19 ; G01N33/574 ; C07K14/705 ; A61P35/04
摘要：
Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6.
公开/授权文献
- US08618254B2 Inhibition of AXL signaling in anti-metastatic therapy 公开/授权日：2013-12-31
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