发明申请
US20130028867A1 LONG-ACTING INTERFERON BETA FORMULATION USING IMMUNOGLOBULIN FRAGMENT
有权
使用免疫抑制蛋白片段的长效干扰素制剂
- 专利标题： LONG-ACTING INTERFERON BETA FORMULATION USING IMMUNOGLOBULIN FRAGMENT
- 专利标题（中）： 使用免疫抑制蛋白片段的长效干扰素制剂
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申请号： US13638821申请日： 2011-04-04
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公开(公告)号： US20130028867A1公开(公告)日： 2013-01-31
- 发明人: Dae Jin Kim , Min Young Kim , Jin Sun Kim , Sung Hee Hong , Sung Youb Jung , Se Chang Kwon
- 申请人： Dae Jin Kim , Min Young Kim , Jin Sun Kim , Sung Hee Hong , Sung Youb Jung , Se Chang Kwon
- 申请人地址： KR Hwaseong-si, Gyeonggi-do
- 专利权人： HANMI SCIENCE CO., LTD.
- 当前专利权人： HANMI SCIENCE CO., LTD.
- 当前专利权人地址： KR Hwaseong-si, Gyeonggi-do
- 优先权： KR10-2010-0030577 20100402
- 国际申请： PCT/KR2011/002335 WO 20110404
- 主分类号： A61K38/21
- IPC分类号： A61K38/21 ; A61P25/28 ; A61P37/06 ; A61P35/00 ; C07K14/565 ; A61P31/12
摘要：
The present invention relates to a long-acting interferon beta formulation having improved in vivo duration and stability, comprising an interferon beta conjugate that is prepared by covalently linking interferon beta with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting interferon beta formulation of the present invention maintains in vivo activity of interferon beta at a relatively high level and remarkably increases the serum half-life thereof, thereby being used for various diseases, for which interferon is efficacious.
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