发明申请
US20130030027A1 HEMI-PHORBOXAZOLE A DERIVATIVES AND METHODS OF THEIR USE
有权
HEMI-PHORBOXAZOLE一种衍生物及其使用方法
- 专利标题： HEMI-PHORBOXAZOLE A DERIVATIVES AND METHODS OF THEIR USE
- 专利标题（中）： HEMI-PHORBOXAZOLE一种衍生物及其使用方法
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申请号： US13386783申请日： 2010-07-23
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公开(公告)号： US20130030027A1公开(公告)日： 2013-01-31
- 发明人: Amos B. Smith, III , Zhuqing Liu , Anne-Marie L. Hogan , Doralyn S. Dalisay , Tadeusz F. Molinski
- 申请人： Amos B. Smith, III , Zhuqing Liu , Anne-Marie L. Hogan , Doralyn S. Dalisay , Tadeusz F. Molinski
- 申请人地址： US CA Oakland US PA Philadelphia
- 专利权人： The Regents of the University of California,The Trustes of The University of Pennsylvania
- 当前专利权人： The Regents of the University of California,The Trustes of The University of Pennsylvania
- 当前专利权人地址： US CA Oakland US PA Philadelphia
- 国际申请： PCT/US10/43020 WO 20100723
- 主分类号： A61K31/424
- IPC分类号： A61K31/424 ; C07D493/22 ; A61K31/357 ; A61P35/00 ; A61K31/427 ; C07D513/22 ; A61K31/422 ; A61P31/10 ; C07D498/22 ; A61K31/381
摘要：
The present invention is directed to hemi phorboxazole A: and its stereoisomers, as well as derivatives of hemi phorboxazole A of formula I: wherein ring A is aryl or a 5- or 6-membered heteroaryl optionally substituted with one or more of halogen, —OH, or —C1-6alkyl; and R is —CN, a 5- or 6-membered heteroaryl, or halogen; and the pharmaceutically acceptable salt forms thereof, in addition to methods of using these compounds.
公开/授权文献
- US08957097B2 Hemi-phorboxazole A derivatives and methods of their use 公开/授权日：2015-02-17
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