发明申请
US20130035377A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2
有权
作为HISTONE DEMETHYLASES LSD1和/或LSD2的抑制剂的衍生物衍生物
- 专利标题： TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2
- 专利标题（中）： 作为HISTONE DEMETHYLASES LSD1和/或LSD2的抑制剂的衍生物衍生物
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申请号： US13641715申请日： 2011-04-15
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公开(公告)号： US20130035377A1公开(公告)日： 2013-02-07
- 发明人: Saverio Minucci , Antonello Mai , Andrea Mattevi
- 申请人： Saverio Minucci , Antonello Mai , Andrea Mattevi
- 申请人地址： IT Roma IT Milano IT Pavia IT Milano
- 专利权人： UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA",UNIVERSITÀ DEGLI STUDI DI MILANO,UNIVERSITÀ DEGLI STUDI DI PAVIA,FONDAZIONE IEO
- 当前专利权人： UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA",UNIVERSITÀ DEGLI STUDI DI MILANO,UNIVERSITÀ DEGLI STUDI DI PAVIA,FONDAZIONE IEO
- 当前专利权人地址： IT Roma IT Milano IT Pavia IT Milano
- 国际申请： PCT/EP2011/055990 WO 20110415
- 主分类号： C07C233/80
- IPC分类号： C07C233/80 ; C07C269/04 ; A61K31/27 ; A61K31/167 ; C07C231/02 ; A61P31/22 ; C07C269/06 ; C07D333/60 ; A61K31/381 ; A61P31/12 ; A61P35/00 ; A61P35/02 ; C07C271/28 ; C07C271/22
摘要：
Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.
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