Invention Application
- Patent Title: Preparation of Lipid Nanoparticles
- Patent Title (中): 脂质纳米颗粒的制备
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Application No.: US13639628Application Date: 2011-04-07
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Publication No.: US20130037977A1Publication Date: 2013-02-14
- Inventor: Paul A. Burke , Marian E. Gindy , David J. Mathre , Varun Kumar , Robert K. Prud'homme
- Applicant: Paul A. Burke , Marian E. Gindy , David J. Mathre , Varun Kumar , Robert K. Prud'homme
- International Application: PCT/US11/31540 WO 20110407
- Main IPC: A61J3/07
- IPC: A61J3/07 ; B82Y5/00 ; B82Y40/00

Abstract:
The present invention provides a process for producing lipid nanoparticles encapsulating therapeutic products, said process comprising: a) providing one or more aqueous solutions in one or more reservoirs; b) providing one or more organic solutions in one or more reservoirs, wherein one or more of the organic solutions contains a lipid and wherein one or more of the aqueous solutions and/or one or more of the organic solutions includes therapeutic products; c) mixing said one or more aqueous solutions with said one or more organic solutions in a first mixing region, wherein said first mixing region is a Multi-Inlet Vortex Mixer (MIVM), wherein said one or more aqueous solutions and said one or more organic solutions are introduced tangentially into a mixing chamber within the MIVM so as to substantially instantaneously produce a lipid nanoparticle solution containing lipid nanoparticles encapsulating therapeutic products.
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