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72 条记录 (耗时 0.031 秒)

    Co-flow microfluidic device for polymersome formation
    1.
    发明授权
    Co-flow microfluidic device for polymersome formation 有权
    用于聚合物组合的共流微流体装置

    公开(公告)号：US08968873B2

    公开(公告)日：2015-03-03

    申请号：US13209183

    申请日：2011-08-12

    申请人： Douglas H. Adamson ,  Michael Stredney ,  Robert K. Prud'homme ,  Mustafa Erhan Yildiz

    发明人： Douglas H. Adamson ,  Michael Stredney ,  Robert K. Prud'homme ,  Mustafa Erhan Yildiz

    IPC分类号： A61K9/127 ,  B05D3/10 ,  C12M1/36 ,  B01J13/04

    CPC分类号： B01J13/04 ,  Y10T137/0402 ,  Y10T428/2985

    摘要： A microfluidic device to produce polymersomes having three coaxial passageways of increasing size with fluid flowing in one direction. The first and smallest passageway contains the content of the polymersome, the middle passageway contains a block copolymer, and the largest and outer passageway contains an aqueous medium or water. The device can produce polymersomes with control of size and membrane thickness. The device will allow quantitative loading of the polymersomes in high quantities. The device is robust and easily assembled and has the ability to independently control the three streams involved in making the polymersomes.

    摘要翻译： 一种微流体装置，用于生产具有三个同轴通道的聚合物囊泡，其中流体在一个方向上流动。 第一和最小的通道包含聚合物的含量，中间通道含有嵌段共聚物，最大和外部通道含有水性介质或水。 该装置可以生产具有尺寸和膜厚度控制的聚合物囊泡。 该装置将允许大量定量加载聚合物囊泡。 该设备坚固耐用，易于组装，并具有独立控制制造聚合物囊泡所涉及的三种流程的能力。

    Co-Flow Microfluidic Device for Polymersome Formation
    2.
    发明申请
    Co-Flow Microfluidic Device for Polymersome Formation 有权
    用于聚合物形成的共流微流体装置

    公开(公告)号：US20120141796A1

    公开(公告)日：2012-06-07

    申请号：US13209183

    申请日：2011-08-12

    申请人： Douglas H. Adamson ,  Michael Stredney ,  Robert K. Prud'homme ,  Mustafa Erhan Yildiz

    发明人： Douglas H. Adamson ,  Michael Stredney ,  Robert K. Prud'homme ,  Mustafa Erhan Yildiz

    IPC分类号： A61K9/127 ,  B32B15/02 ,  B23P11/00

    CPC分类号： B01J13/04 ,  Y10T137/0402 ,  Y10T428/2985

    摘要： A microfluidic device to produce polymersomes having three coaxial passageways of increasing size with fluid flowing in one direction. The first and smallest passageway contains the content of the polymersome, the middle passageway contains a block copolymer, and the largest and outer passageway contains an aqueous medium or water. The device can produce polymersomes with control of size and membrane thickness. The device will allow quantitative loading of the polymersomes in high quantities. The device is robust and easily assembled and has the ability to independently control the three streams involved in making the polymersomes.

    摘要翻译： 一种微流体装置，用于生产具有三个同轴通道的聚合物囊泡，其中流体在一个方向上流动。 第一和最小的通道包含聚合物的含量，中间通道含有嵌段共聚物，最大和外部通道含有水性介质或水。 该装置可以生产具有尺寸和膜厚度控制的聚合物囊泡。 该装置将允许大量定量加载聚合物囊泡。 该设备坚固耐用，易于组装，并具有独立控制制造聚合物囊泡所涉及的三种流程的能力。

    Enzyme immobilization by imbibing an enzyme solution into dehydrated hydrocolloid gel beads
    10.
    发明授权
    Enzyme immobilization by imbibing an enzyme solution into dehydrated hydrocolloid gel beads 失效
    通过将酶溶液吸收到脱水的水胶体凝胶珠中来进行酶固定

    公开(公告)号：US06268191B1

    公开(公告)日：2001-07-31

    申请号：US09395465

    申请日：1999-09-14

    申请人： Robert K. Prud'homme ,  Catherine-Ann Cukras ,  Henry A. Pfeffer

    发明人： Robert K. Prud'homme ,  Catherine-Ann Cukras ,  Henry A. Pfeffer

    IPC分类号： C12N1110

    CPC分类号： C12Y304/21062 ,  C12N11/02 ,  C12N11/10 ,  C12P17/10

    摘要： Enzymes are immobilized for use in non-aqueous enzymatic reactions by dehydrating hydrocolloid gel beads having an average particle size of 5 to 150 microns and a network structure capable of swelling in aqueous media, immersing or suspending the dehyrated gel beads in an aqueous solution of enzyme where the beads swell and imbibe the enzyme solution, optionally dehydrating the resultant enzyme-containing gel beads and recovering the gel beads containing the enzyme. In a specific method, the hydrocolloid is carrageenan such a kappa carragennan, the enzyme is subtilisin Carlsberg, the aqueous enzyme solution contains 0.05% to 40 wt % enzyme and the amount of enzyme imbibed is 0.05 to 0.5 grams of enzyme per gram of dehydrated gel beads.

    摘要翻译： 通过使平均粒径为5至150微米的水胶体凝胶珠脱水，并在水性介质中能够溶胀的网状结构，将脱胶的凝胶珠浸入酶水溶液中，使酶固定化用于非水性酶反应 其中珠子溶胀并吸收酶溶液，任选地使得到的含酶凝胶珠脱水并回收含有该酶的凝胶珠。 在具体的方法中，水胶体是角叉菜胶，如卡拉胶（kappa carragennan），酶是枯草杆菌蛋白酶（Carlsberg），酶水溶液含有0.05％至40％重量的酶，每克脱水凝胶中所含酶的量为0.05至0.5克酶 珠子