Invention Application
US20130040952A1 INFLUENZA VIRUS INHIBITORS THAT DISRUPT NUCLEOPROTEIN TRIMERIZATION
审中-公开
流感病毒抑制剂阻断核糖核酸二聚体
- Patent Title: INFLUENZA VIRUS INHIBITORS THAT DISRUPT NUCLEOPROTEIN TRIMERIZATION
- Patent Title (中): 流感病毒抑制剂阻断核糖核酸二聚体
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Application No.: US13567355Application Date: 2012-08-06
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Publication No.: US20130040952A1Publication Date: 2013-02-14
- Inventor: Chi-Huey Wong , Ming-Daw Tsai , Ying-Ta Wu , Yih-Shyun E. Cheng , Yu-Hou Chen , Yu-Fang Shen
- Applicant: Chi-Huey Wong , Ming-Daw Tsai , Ying-Ta Wu , Yih-Shyun E. Cheng , Yu-Hou Chen , Yu-Fang Shen
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C12N5/07 ; A61P31/16 ; G01N33/53 ; A61K31/167 ; A61K31/517
Abstract:
Methods for identifying agents capable of disrupting a salt bridge in an influenza A virus nucleoprotein corresponding to the E339 . . . R416 salt bridge in SEQ ID NO:1, and thus the trimerization of the NP protein; and uses of such agents, e.g., small molecules and peptides, for inhibiting influenza virus replication and treating infection caused by influenza virus.
Information query
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