公开(公告)号：US06552007B2

公开(公告)日：2003-04-22

申请号：US09734298

申请日：2000-12-11

Applicant: Shui-Tein Chen ,  Ying-Ta Wu ,  Chun-Ming Huang

Inventor： Shui-Tein Chen ,  Ying-Ta Wu ,  Chun-Ming Huang

IPC: A01N5700

CPC classification number: A61K47/6911 ,  A61K47/55 ,  A61K47/64

Abstract: A conjugate of somatostatin-spacer-drug and a method of making the same. The conjugate can be used to enhance an anti-cancer drug's specificity on the targeted tumor cells, thus increasing its therapeutic efficacy while reducing side-effects.

Abstract translation: 生长抑素间隔物药物的共轭物及其制备方法。 该缀合物可用于增强靶向肿瘤细胞的抗癌药物的特异性，从而提高治疗效果，同时降低副作用。

公开(公告)号：US20130345223A9

公开(公告)日：2013-12-26

申请号：US13806228

申请日：2011-06-28

Applicant: Chi-Huey Wong ,  Ying-Ta Wu

Inventor： Chi-Huey Wong ,  Ying-Ta Wu

IPC: C07D498/04 ,  C07D405/14 ,  C07D417/14 ,  C07C49/755 ,  C07D413/14 ,  C07D487/04 ,  C07D401/12

CPC classification number: C07D498/04 ,  C07C49/753 ,  C07C49/755 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: The present invention provides compounds which are potent inhibitors against Lpd activity, PDH activity, and/or the growth of tubercle bacillus, and thus are useful in the treatment of tuberculosis infection and associated conditions. The present invention is further directed to in vitro- and in vzivo-based methods of inhibiting Lpd and/or PDH activity. In certain embodiments, these methods are useful in inhibiting Lpd and/or PDH activity key to a pathogen's survival.

Abstract translation: 本发明提供了对Lpd活性，PDH活性和/或结核杆菌生长有效的抑制剂的化合物，因此可用于治疗结核病感染和相关病症。 本发明还涉及基于体外和基于vzivo的抑制Lpd和/或PDH活性的方法。 在某些实施方案中，这些方法可用于抑制病原体存活的Lpd和/或PDH活性。

公开(公告)号：US20130158037A1

公开(公告)日：2013-06-20

申请号：US13806228

申请日：2011-06-28

Applicant: Chi-Huey Wong ,  Ying-Ta Wu

Inventor： Chi-Huey Wong ,  Ying-Ta Wu

IPC: C07D498/04 ,  C07D405/14 ,  C07D417/14 ,  C07C49/755 ,  C07D413/14 ,  C07D487/04 ,  C07D401/12

CPC classification number: C07D498/04 ,  C07C49/753 ,  C07C49/755 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: The present invention provides compounds which are potent inhibitors against Lpd activity, PDH activity, and/or the growth of tubercle bacillus, and thus are useful in the treatment of tuberculosis infection and associated conditions. The present invention is further directed to in vitro- and in vzivo-based methods of inhibiting Lpd and/or PDH activity. In certain embodiments, these methods are useful in inhibiting Lpd and/or PDH activity key to a pathogen's survival.

公开(公告)号：US09073941B2

公开(公告)日：2015-07-07

申请号：US13806228

申请日：2011-06-28

Applicant: Chi-Huey Wong ,  Ying-Ta Wu

Inventor： Chi-Huey Wong ,  Ying-Ta Wu

IPC: A61K31/415 ,  C07D498/04 ,  C07C49/753 ,  C07C49/755 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

CPC classification number: C07D498/04 ,  C07C49/753 ,  C07C49/755 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: The present invention provides compounds which are potent inhibitors against Lpd activity, PDH activity, and/or the growth of tubercle bacillus, and thus are useful in the treatment of tuberculosis infection and associated conditions. The present invention is further directed to in vitro- and in vzivo-based methods of inhibiting Lpd and/or PDH activity. In certain embodiments, these methods are useful in inhibiting Lpd and/or PDH activity key to a pathogen's survival.

Abstract translation: 本发明提供了对Lpd活性，PDH活性和/或结核杆菌生长有效的抑制剂的化合物，因此可用于治疗结核病感染和相关病症。 本发明还涉及基于体外和基于vzivo的抑制Lpd和/或PDH活性的方法。 在某些实施方案中，这些方法可用于抑制病原体存活的Lpd和/或PDH活性。

公开(公告)号：US20130040952A1

公开(公告)日：2013-02-14

申请号：US13567355

申请日：2012-08-06

Applicant: Chi-Huey Wong ,  Ming-Daw Tsai ,  Ying-Ta Wu ,  Yih-Shyun E. Cheng ,  Yu-Hou Chen ,  Yu-Fang Shen

Inventor： Chi-Huey Wong ,  Ming-Daw Tsai ,  Ying-Ta Wu ,  Yih-Shyun E. Cheng ,  Yu-Hou Chen ,  Yu-Fang Shen

IPC: A61K31/5377 ,  C12N5/07 ,  A61P31/16 ,  G01N33/53 ,  A61K31/167 ,  A61K31/517

CPC classification number: A61K31/167 ,  A61K31/517 ,  A61K31/5377 ,  G01N33/56983

Abstract: Methods for identifying agents capable of disrupting a salt bridge in an influenza A virus nucleoprotein corresponding to the E339 . . . R416 salt bridge in SEQ ID NO:1, and thus the trimerization of the NP protein; and uses of such agents, e.g., small molecules and peptides, for inhibiting influenza virus replication and treating infection caused by influenza virus.

Abstract translation: 鉴定能够破坏对应于E339的甲型流感病毒核蛋白中的盐桥的试剂的方法。 。 。 R416盐桥，因此NP蛋白的三聚化; 以及这些药剂（例如小分子和肽）用于抑制流感病毒复制和治疗由流感病毒引起的感染的用途。