- 专利标题: MODULATORS OF FATTY ACID AMIDE HYDROLASE
-
申请号: US13695855申请日: 2011-05-02
-
公开(公告)号: US20130053398A1公开(公告)日: 2013-02-28
- 发明人: John M. Keith , Jing Liu
- 申请人: John M. Keith , Jing Liu
- 申请人地址: US NJ New Brunswick
- 专利权人: Janssen Pharmaceutica NV
- 当前专利权人: Janssen Pharmaceutica NV
- 当前专利权人地址: US NJ New Brunswick
- 国际申请: PCT/US11/34755 WO 20110502
- 主分类号: C07D405/14
- IPC分类号: C07D405/14 ; A61K31/496 ; A61P25/22 ; A61P25/24 ; A61P29/00 ; A61P3/00 ; A61P25/08 ; A61P25/16 ; A61P35/00 ; A61P3/10 ; A61P25/00 ; A61P19/08 ; C12N9/99 ; A61P25/28
摘要:
4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is described, which is useful as a FAAH modulator. 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). A method of synthesizing 4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is also disclosed.
公开/授权文献
- US08940745B2 Modulators of fatty acid amide hydrolase 公开/授权日:2015-01-27
信息查询