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公开(公告)号：US08940745B2
公开(公告)日：2015-01-27
申请号：US13695855
申请日：2011-05-02
申请人： John M. Keith , Jing Liu
发明人： John M. Keith , Jing Liu
IPC分类号： C07D405/12 , A61K31/496
CPC分类号： C07D405/12
摘要： 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is described, which is useful as a FAAH modulator. 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). A method of synthesizing 4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is also disclosed.
摘要翻译： 描述了4-（2,2-二氟 - 苯并[1,3]二氧杂环戊烯-5-基甲基） - 哌嗪-1-甲酸（4-氯 - 吡啶-3-基） - 酰胺，其可用作FAAH 调制器。 4-（2,2-二氟 - 苯并[1,3]二氧杂环戊烯-5-基甲基） - 哌嗪-1-甲酸（4-氯 - 吡啶-3-基） - 酰胺可用于药物组合物和方法 治疗由脂肪酸酰胺水解酶（FAAH）活性（如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，能量代谢紊乱和运动障碍（例如多发性硬化））介导的疾病状态，病症和状况。 还公开了合成4-（2,2-二氟 - 苯并[1,3]二氧杂环戊烯-5-基甲基） - 哌嗪-1-甲酸（4-氯 - 吡啶-3-基） - 酰胺的方法。
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公开(公告)号：US20130053398A1
公开(公告)日：2013-02-28
申请号：US13695855
申请日：2011-05-02
申请人： John M. Keith , Jing Liu
发明人： John M. Keith , Jing Liu
IPC分类号： C07D405/14 , A61K31/496 , A61P25/22 , A61P25/24 , A61P29/00 , A61P3/00 , A61P25/08 , A61P25/16 , A61P35/00 , A61P3/10 , A61P25/00 , A61P19/08 , C12N9/99 , A61P25/28
CPC分类号： C07D405/12
摘要： 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is described, which is useful as a FAAH modulator. 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). A method of synthesizing 4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is also disclosed.
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公开(公告)号：US10992555B2
公开(公告)日：2021-04-27
申请号：US12791704
申请日：2010-06-01
申请人： Kishor Kakatkar , Roy Nakashima , Rosanna Lee , Jing Liu , Derek Sanders , Rangaswamy Jagannathan , David Messina
发明人： Kishor Kakatkar , Roy Nakashima , Rosanna Lee , Jing Liu , Derek Sanders , Rangaswamy Jagannathan , David Messina
摘要： Network monitoring views can be recorded, replayed and shared. A monitoring system receives monitoring data, in response to which a monitoring view can be constructed. The monitoring data is maintained in memory or mass storage. One or more monitoring views can later be constructed in response to user preferences, even if those users would not have known to select those particular preferences or construct those particular monitoring views at the time. The monitoring views constructed in response to that monitoring data can be presented to users in a simulation of the problem, as if it were occurring at that time. Users can send particular monitoring views to others, with both the effects that the monitoring view can be preserved as part of a trouble report, and the persons receiving the monitoring view can have useful insight into what problem the user has pointed to.
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公开(公告)号：US09607509B2
公开(公告)日：2017-03-28
申请号：US14681122
申请日：2015-04-08
申请人： Jing Liu , Junpeng Hu , Yinling Ni , Yongxun Li , Siyi Chen , Jun Liu
发明人： Jing Liu , Junpeng Hu , Yinling Ni , Yongxun Li , Siyi Chen , Jun Liu
CPC分类号： G08G1/0125 , G01S1/026 , G08G1/0116 , G08G1/0129 , G08G1/017 , G08G1/0175 , G08G1/144 , G08G1/147
摘要： A framework for identifying parking areas from vehicle trajectory data is described herein. Vehicle trajectory data collected from a sensor network having a plurality of sensor stations for detecting vehicles is provided. The vehicle trajectory data is pre-processed to generate a tracking table of vehicles and analyzed to determine an interstation parking area between first and second sensor stations of interest based on input parameters from a user.
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公开(公告)号：US09421308B2
公开(公告)日：2016-08-23
申请号：US14000726
申请日：2012-02-21
申请人： Jing Liu , Rahul Bhardwaj
发明人： Jing Liu , Rahul Bhardwaj
CPC分类号： A61L31/041 , C08L67/02 , C08L81/06 , C08L25/14
摘要： A compound suitable for hydroclaving is disclosed, comprising polyester, polysulfone, and an epoxy-functional styrene-acrylate oligomer. In order for successful repetitious hydroclaving to be possible, the compound must also have a polysulfone content of greater than 45 weight percent of the compound.
摘要翻译： 公开了一种适用于水压剥离的化合物，包括聚酯，聚砜和环氧官能的苯乙烯 - 丙烯酸酯低聚物。 为了能够成功地进行重复的水压剥离，化合物还必须具有大于化合物重量比45重量％的聚砜含量。
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公开(公告)号：US08719308B2
公开(公告)日：2014-05-06
申请号：US12371806
申请日：2009-02-16
申请人： Wuzhen Xiong , Bing Tang , Jing Liu , Han Yang , Xiaolu Dai
发明人： Wuzhen Xiong , Bing Tang , Jing Liu , Han Yang , Xiaolu Dai
CPC分类号： G06F17/30684
摘要： A system to process unstructured data is provided. An example system to process unstructured data comprises a receiver to access a source of unstructured data, an entity extractor to extract entity instances from the source of unstructured data and organize the extracted entity instances into an entity instance table, a pattern generator to generate a pattern comprising a key entity and one or more non-key entities associated with the key entity based on the entity instance table, and a dataset generator to generate a two-dimensional table based on the pattern and the entity instance table.
摘要翻译： 提供了一种处理非结构化数据的系统。 用于处理非结构化数据的示例系统包括：接收器，用于访问非结构化数据源;实体提取器，用于从非结构化数据源提取实体实例，并将提取的实体实例组织到实体实例表中;模式生成器，用于生成模式 包括基于所述实体实例表与所述密钥实体相关联的密钥实体和一个或多个非密钥实体，以及基于所述模式和所述实体实例表生成二维表的数据集生成器。
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公开(公告)号：US08639797B1
公开(公告)日：2014-01-28
申请号：US12180243
申请日：2008-07-25
申请人： Xiaohong Pan , Kishor Kakatkar , Derek Sanders , Rangaswamy Jagannathan , Jing Liu , Rosanna Lee
发明人： Xiaohong Pan , Kishor Kakatkar , Derek Sanders , Rangaswamy Jagannathan , Jing Liu , Rosanna Lee
IPC分类号： G06F15/173
CPC分类号： H04L43/12 , H04L41/142 , H04L43/04 , H04L43/062
摘要： A network monitoring system maintains both information regarding historical activity of a network, and information regarding emergent activity of the network. Comparison of historical activity of the network with emergent activity of the network allows the system to determine whether network activity is changing over time. The network monitoring system maintains data structures representing a p.d.f. for observable values of network parameters. Recent activity of the network can be compared with both the p.d.f. for historical activity and for emergent activity to aid in determining whether that recent activity is within the realm of normal, and whether network activity is changing over time. The network monitoring system adjusts that information regarding historical activity of a network in response to emergent activity of that network. The network monitoring device determines information regarding time-dependent activity of that network in response to spectral analysis regarding historical activity of that network.
摘要翻译： 网络监控系统维护关于网络的历史活动的信息和关于网络的紧急活动的信息。 网络的历史活动与网络紧急活动的比较允许系统确定网络活动是否随时间而变化。 网络监控系统维护表示p.d.f.的数据结构。 用于网络参数的可观察值。 网络的最近活动可以与p.d.f. 用于历史活动和紧急活动，以帮助确定最近的活动是否在正常范围内，以及网络活动是否随时间而变化。 网络监控系统根据网络的紧急活动调整有关网络历史活动的信息。 响应于关于该网络的历史活动的频谱分析，网络监视设备确定关于该网络的时间相关活动的信息。
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公开(公告)号：US20130323121A1
公开(公告)日：2013-12-05
申请号：US14000726
申请日：2012-02-21
申请人： Jing Liu , Rahul Bhardwaj
发明人： Jing Liu , Rahul Bhardwaj
IPC分类号： A61L31/04
CPC分类号： A61L31/041 , C08L67/02 , C08L81/06 , C08L25/14
摘要： A compound suitable for hydroclaving is disclosed, comprising polyester, polysulfone, and an epoxy-functional styrene-acrylate oligomer. In order for successful repetitious hydroclaving to be possible, the compound must also have a polysulfone content of greater than 45 weight percent of the compound.
摘要翻译： 公开了一种适用于水压剥离的化合物，包括聚酯，聚砜和环氧官能的苯乙烯 - 丙烯酸酯低聚物。 为了能够成功地进行重复的水压剥离，化合物还必须具有大于化合物重量比45重量％的聚砜含量。
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公开(公告)号：US08451731B1
公开(公告)日：2013-05-28
申请号：US12180193
申请日：2008-07-25
申请人： Rosanna Lee , Hong Zhu , Rangaswamy Jagannathan , Xiaohong Pan , Derek Sanders , Kishor Kakatkar , Jing Liu
发明人： Rosanna Lee , Hong Zhu , Rangaswamy Jagannathan , Xiaohong Pan , Derek Sanders , Kishor Kakatkar , Jing Liu
IPC分类号： H04J1/16 , H04J3/14 , G06F15/173
CPC分类号： H04L41/0645 , H04L43/00 , H04L43/022 , H04L43/026 , H04L43/04 , H04L43/0817 , Y02D50/30
摘要： A network monitoring device includes a flow processing element, disposed to receive flow information relating to network flows, and to generate a set of virtual packets, each representing a portion of a network flow. The virtual packets are maintained in a time-sequential order, and read by elements of the network monitoring device to generate information relating to network traffic, such as symptoms affecting the communication network, problems affecting the communication network, and otherwise. The network monitoring device randomly samples virtual packets, with at least one of two effects: (1) flow information from traffic reporting devices that are themselves sampling at differing rates can be equalized, with the effect of standardizing information from all of them; (2) the network monitoring device itself can restrict its attention to a fraction of all virtual packets, with the effect of keeping up with a relatively large number of virtual packets.
摘要翻译： 网络监视设备包括流处理元件，其被设置为接收与网络流相关的流信息，并且生成一组虚拟分组，每组虚拟分组表示网络流的一部分。 虚拟分组以时间顺序的顺序进行维护，并由网络监控设备的元素进行读取，以产生与网络流量相关的信息，例如影响通信网络的症状，影响通信网络的问题等。 网络监控设备随机采样虚拟数据包，具有以下两个效果中的至少一个：（1）流量报告设备本身以不同速率进行采样的流量信息可以均衡化，并使其全部信息标准化; （2）网络监控设备本身可以将其注意力限制在所有虚拟分组的一小部分，具有跟上相对较大数量的虚拟分组的效果。
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公开(公告)号：US20130017250A1
公开(公告)日：2013-01-17
申请号：US13550567
申请日：2012-07-16
申请人： Henry Ginsberg , Jing Liu
发明人： Henry Ginsberg , Jing Liu
摘要： It was discovered that insulin binding to insulin receptors signals the upregulation of expression of the liver enzyme deiodinase 1 (Dio1), which in turn activates the ApoA-1 promoter, thereby thereby increasing ApoA-1 expression (primarily in the liver), that in turn raises the levels of plasma ApoA-1, the major and necessary protein in HDLC. Certain embodiments of the invention are directed to methods for increasing circulating HDLC levels in an animal by administering therapeutically effective amounts of Dio1, or by increasing the level of Dio1 through gene therapy.
摘要翻译： 发现与胰岛素受体结合的胰岛素信号表明肝酶脱碘酶1（Dio1）的表达上调，其反过来激活ApoA-1启动子，从而增加ApoA-1表达（主要在肝脏中）， 转向提高血浆ApoA-1的水平，HDA是HDLC中主要和必需的蛋白质。 本发明的某些实施方案涉及通过施用治疗有效量的Dio1或通过基因治疗增加Dio1的水平来增加动物中循环HDLC水平的方法。
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