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    Modulators of fatty acid amide hydrolase
    1.
    发明授权
    Modulators of fatty acid amide hydrolase 有权
    脂肪酸酰胺水解酶的调节剂

    公开(公告)号：US08940745B2

    公开(公告)日：2015-01-27

    申请号：US13695855

    申请日：2011-05-02

    申请人： John M. Keith ,  Jing Liu

    发明人： John M. Keith ,  Jing Liu

    IPC分类号： C07D405/12 ,  A61K31/496

    CPC分类号： C07D405/12

    摘要： 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is described, which is useful as a FAAH modulator. 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). A method of synthesizing 4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is also disclosed.

    摘要翻译： 描述了4-（2,2-二氟 - 苯并[1,3]二氧杂环戊烯-5-基甲基） - 哌嗪-1-甲酸（4-氯 - 吡啶-3-基） - 酰胺，其可用作FAAH 调制器。 4-（2,2-二氟 - 苯并[1,3]二氧杂环戊烯-5-基甲基） - 哌嗪-1-甲酸（4-氯 - 吡啶-3-基） - 酰胺可用于药物组合物和方法 治疗由脂肪酸酰胺水解酶（FAAH）活性（如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，能量代谢紊乱和运动障碍（例如多发性硬化））介导的疾病状态，病症和状况。 还公开了合成4-（2,2-二氟 - 苯并[1,3]二氧杂环戊烯-5-基甲基） - 哌嗪-1-甲酸（4-氯 - 吡啶-3-基） - 酰胺的方法。

    Adaptive digital video compression system
    6.
    发明授权
    Adaptive digital video compression system 失效
    自适应数字视频压缩系统

    公开(公告)号：US5225904A

    公开(公告)日：1993-07-06

    申请号：US802169

    申请日：1991-12-04

    申请人： Stuart J. Golin ,  Allen H. Simon ,  Brian Astle ,  John M. Keith

    发明人： Stuart J. Golin ,  Allen H. Simon ,  Brian Astle ,  John M. Keith

    IPC分类号： H04N5/85 ,  H04N7/24 ,  H04N7/26 ,  H04N7/32 ,  H04N9/806

    CPC分类号： H04N19/186 ,  H04N19/10 ,  H04N19/50 ,  H04N7/24 ,  H04N9/8066 ,  H04N5/85

    摘要： A full motion color digital video signal is compressed, formatted for transmission, recorded on compact disc media and decoded at conventional video frame rates. During compression, regions of a frame are individually analyzed to select optimum fill coding methods specific to each region. Region decoding time estimates are made to optimize compression thresholds. Region descriptive codes conveying the size and locations of the regions are grouped together in a first segment of a data stream. Region fill codes conveying pixel amplitude indications for the regions are grouped together according to fill code type and placed in other segments of the data stream. The data stream segments are individually variable length coded according to their respective statistical distributions and formatted to form data frames. The number of bytes per frame is dithered by the addition of auxiliary data determined by a reverse frame sequence analysis to provide an average number selected to minimize pauses of the compact disc during playback thereby avoiding unpredictable seek mode latency periods characteristic of compact discs. A decoder includes a variable length decoder responsive to statistical information in the code stream for separately variable length decoding individual segments of the data stream. Region location data is derived from region descriptive data and applied with region fill codes to a plurality of region specific decoders selected by detection of the fill code type (e.g., relative, absolute, dyad and DPCM) and decoded region pixels are stored in a bit map for subsequent display.

    摘要翻译： 全运动彩色数字视频信号被压缩，格式化用于传输，记录在光盘介质上并以常规视频帧速率进行解码。 在压缩期间，单独地分析帧的区域以选择对于每个区域特定的最佳填充编码方法。 进行区域解码时间估计以优化压缩阈值。 将区域的尺寸和位置的区域描述代码分组在数据流的第一段中。 传送区域的像素幅度指示的区域填充代码根据填充代码类型分组在一起并放置在数据流的其他段中。 数据流段根据各自的统计分布进行单独变长编码，并进行格式化以形成数据帧。 通过添加由反向帧序列分析确定的辅助数据来提供每帧的字节数，以提供所选择的平均数，以在重放期间最小化压缩盘的暂停，从而避免光盘特征的不可预测的寻道模式等待时间周期。 解码器包括响应于代码流中的统计信息的可变长度解码器，用于单独变长数据流解码数据流的各个段。 区域位置数据从区域描述数据导出，并且通过区域填充码应用于通过检测填充码类型（例如，相对，绝对，二进制和DPCM）选择的多个区域特定解码器，并将解码的区域像素存储在位中 地图以供后续显示。

    Adaptive video compression system
    7.
    发明授权
    Adaptive video compression system 失效
    自适应视频压缩系统

    公开(公告)号：US5079630A

    公开(公告)日：1992-01-07

    申请号：US408085

    申请日：1989-09-15

    申请人： Stuart J. Golin ,  Allen H. Simon ,  Brian Astle ,  John M. Keith

    发明人： Stuart J. Golin ,  Allen H. Simon ,  Brian Astle ,  John M. Keith

    IPC分类号： H04N5/85 ,  H04N7/24 ,  H04N7/26 ,  H04N7/32 ,  H04N9/806

    CPC分类号： H04N19/186 ,  H04N19/10 ,  H04N19/50 ,  H04N7/24 ,  H04N9/8066 ,  H04N5/85

    摘要： A full motion color digital video signal is compressed, formatted for transmission, recorded on compact disc media and decoded at conventional video frame rates. During compression, regions of a frame are individually analyzed to select optimum fill coding methods specific to each region. Region decoding time estimates are made to optimize compression thresholds. Region descriptive codes conveying the size and locations of the regions are grouped together in a first segment of a data stream. Region fill codes conveying pixel amplitude indications for the regions are grouped together according to fill code type and placed in other segments of the data stream. The data stream segments are individually variable length coded according to their respective statistical distributions and formatted to form data frames. The number of bytes per frame is dithered by the addition of auxiliary data determined by a reverse frame sequence analysis to provided an average number selected to minimize pauses of the compact disc during playback thereby avoiding unpredicatable seek mode latency periods characteristic of compact discs. A decoder includes a variable length decoder responsive to statistical information in the code stream for separately variable length decoding individual segments of the data stream. Region location data is derived from region descriptive data and applied with region fill codes to a plurality of region specific decoders selected by detection of the fill code type (e.g., relative, absolute, dyad and DPCM) and decoded region pixels are stored in a bit map for subsequent display.

    摘要翻译： 全运动彩色数字视频信号被压缩，格式化用于传输，记录在光盘介质上并以常规视频帧速率进行解码。 在压缩期间，单独地分析帧的区域以选择对于每个区域特定的最佳填充编码方法。 进行区域解码时间估计以优化压缩阈值。 将区域的尺寸和位置的区域描述代码分组在数据流的第一段中。 传送区域的像素幅度指示的区域填充代码根据填充代码类型分组在一起并放置在数据流的其他段中。 数据流段根据各自的统计分布进行单独变长编码，并进行格式化以形成数据帧。 通过添加由反向帧序列分析确定的辅助数据来提供每帧的字节数，以提供在重放期间最小化光盘暂停的平均数，从而避免光盘特征的不可预测的寻道模式等待时间周期。 解码器包括响应于代码流中的统计信息的可变长度解码器，用于单独变长数据流解码数据流的各个段。 区域位置数据从区域描述数据导出，并且通过区域填充码应用于通过检测填充码类型（例如，相对，绝对，二进制和DPCM）选择的多个区域特定解码器，并将解码的区域像素存储在位中 地图以供后续显示。

    Adaptive digital video compression system
    8.
    发明授权
    Adaptive digital video compression system 失效
    自适应数字视频压缩系统

    公开(公告)号：US4868653A

    公开(公告)日：1989-09-19

    申请号：US104457

    申请日：1987-10-05

    申请人： Stuart J. Golin ,  Allen H. Simon ,  Brian Astle ,  John M. Keith

    发明人： Stuart J. Golin ,  Allen H. Simon ,  Brian Astle ,  John M. Keith

    IPC分类号： H04N9/804 ,  H04N1/41 ,  H04N5/85 ,  H04N7/24 ,  H04N7/26 ,  H04N7/32 ,  H04N9/806 ,  H04N9/808

    CPC分类号： H04N9/8066 ,  H04N19/10 ,  H04N19/186 ,  H04N19/50 ,  H04N7/24 ,  H04N5/85

    摘要： A full motion color digital video signal is compressed, formatted for transmission, recorded on compact disc media and decoded at conventional video frame rates. During compression, regions of a frame are individually analyzed to select optimum fill coding methods specific to each region. Region decoding time estimates are made to optimize compression thresholds. Region descriptive codes conveying the size and locations of the regions are grouped together in a first segment of a data stream. Region fill codes conveying pixel amplitude indications for the regions are grouped together according to fill code type and placed in other segments of the data stream. The data stream segments are individually variable length coded according to their respective statistical distributions and formatted to form data frames. The number of bytes per frame is dithered by the addition of auxiliary data determined by a reverse frame sequence analysis to provide an average number selected to minimize pauses of the compact disc during playback thereby avoiding unpredictable seek mode latency periods characteristic of compact discs. A decoder includes a variable length decoder responsive to statistical information in the code stream for separately variable length decoding individual segments of the data stream. Region location data is derived from region descriptive data and applied with region fill codes to a plurality of region specific decoders selected by detection of the fill code type (e.g., relative, absolute, dyad and DPCM) and decoded region pixels are stored in a bit map for subsequent display.

    摘要翻译： 全运动彩色数字视频信号被压缩，格式化用于传输，记录在光盘介质上并以常规视频帧速率进行解码。 在压缩期间，单独地分析帧的区域以选择对于每个区域特定的最佳填充编码方法。 进行区域解码时间估计以优化压缩阈值。 将区域的尺寸和位置的区域描述代码分组在数据流的第一段中。 传送区域的像素幅度指示的区域填充代码根据填充代码类型分组在一起并放置在数据流的其他段中。 数据流段根据各自的统计分布进行单独变长编码，并进行格式化以形成数据帧。 通过添加由反向帧序列分析确定的辅助数据来提供每帧的字节数，以提供所选择的平均数，以在重放期间最小化压缩盘的暂停，从而避免光盘特征的不可预测的寻道模式等待时间周期。 解码器包括响应于代码流中的统计信息的可变长度解码器，用于单独变长数据流解码数据流的各个段。 区域位置数据从区域描述数据导出，并且通过区域填充码应用于通过检测填充码类型（例如，相对，绝对，二进制和DPCM）选择的多个区域特定解码器，并将解码的区域像素存储在位中 地图以供后续显示。

    Method and apparatus for expanding compressed video data
    9.
    发明授权
    Method and apparatus for expanding compressed video data 失效
    用于扩展压缩视频数据的方法和装置

    公开(公告)号：US4835607A

    公开(公告)日：1989-05-30

    申请号：US121818

    申请日：1987-11-16

    申请人： John M. Keith

    发明人： John M. Keith

    IPC分类号： H04N7/26 ,  H04N7/36 ,  H04N7/46

    CPC分类号： H04N19/00 ,  H04N19/503 ,  H04N19/587 ,  H04N19/59

    摘要： A processor which expands a compressed video signal is disclosed. The compressed video signal applied to the processor is generated by partitioning a video image into segments and then describing how each segment is filled by using a bilinear equation, that is to say, a linear equation which is a function of a horizontal coordinate X and a vertical coordinate Y. The coefficients of the X and Y coordinates each include integer and fractional parts. The circuitry develops a table of values from the coefficient of the X coordinate by repeatedly adding the coefficient in an accumulator. As each sum is produced, the integer part of the sum is stored. The table of values is developed from the stored integer sums as the difference between alternate sums, where successive alternate pairs of sums are interleaved. For example, the table would include the difference between the first and third sums followed by the difference between the second and fourth sums, then the third and fifth sums and so on. The segment is reconstructed by accumulating alternate ones of the table entries in separate adders. At each stage in the accumulation, the output values of the two adders are two successive pixel values along the horizontal coordinate of the segment.

    摘要翻译： 公开了一种扩展压缩视频信号的处理器。 通过将视频图像分割成段，然后通过使用双线性方程（即，作为水平坐标X和A的函数的线性方程）描述如何填充每个段来生成施加到处理器的压缩视频信号 垂直坐标Y.X和Y坐标的系数各包括整数和小数部分。 该电路通过在累加器中反复添加系数，从X坐标的系数开始产生一个值表。 当产生每个和时，存储和的整数部分。 值表是从存储的整数和作为交替和之间的差异开发的，其中相加的交替对的并行交错。 例如，该表将包括第一和第三和之后的差值，之后是第二和第四和之差，然后是第三和第五和等等。 通过在单独的加法器中累加替代的表条目来重构段。 在积累的每个阶段，两个加法器的输出值是沿着该段的水平坐标的两个连续的像素值。