发明申请
US20130060049A1 METHOD FOR PREPARING (S)-4-HYDROXY-2-OXO-1-PYRROLIDINE ACETAMIDE
审中-公开
制备（S）-4-羟基-2-氧代-1-吡咯烷酮乙酰胺的方法
- 专利标题： METHOD FOR PREPARING (S)-4-HYDROXY-2-OXO-1-PYRROLIDINE ACETAMIDE
- 专利标题（中）： 制备（S）-4-羟基-2-氧代-1-吡咯烷酮乙酰胺的方法
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申请号： US13581832申请日： 2010-09-09
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公开(公告)号： US20130060049A1公开(公告)日： 2013-03-07
- 发明人: Chao You , Hua Feng , Qi Pang , Lei Ye , Yuying Chen , Zuyuan Rong , Lei Jin , Nan Xu , Fei Li , Bo Li
- 申请人： Chao You , Hua Feng , Qi Pang , Lei Ye , Yuying Chen , Zuyuan Rong , Lei Jin , Nan Xu , Fei Li , Bo Li
- 优先权： CN201010179830.7 20100521
- 国际申请： PCT/CN10/76758 WO 20100909
- 主分类号： C07D207/12
- IPC分类号： C07D207/12
摘要：
A preparation method of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide is provided, which includes the steps of preparing the crude product and crystallizing, wherein acetone and water are used as solvents in the step of crystallizing. The (S)-oxiracetam prepared by the method of the present invention has high purity of more than 99.3% and low impurity of 0-0.5%, based on the percentages of the mass. According to the method of the present invention, with regard to the way of charging materials, adding inorganic base only just a few times is easier to handle and more convenient to the industrial manufacturing and application.
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