发明申请
US20130065859A1 SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
有权
取代的2-（CHROMAN-6-YLOXY）-THIAZOLES及其作为药物的用途
- 专利标题： SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
- 专利标题（中）： 取代的2-（CHROMAN-6-YLOXY）-THIAZOLES及其作为药物的用途
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申请号： US13230357申请日： 2011-09-12
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公开(公告)号： US20130065859A1公开(公告)日： 2013-03-14
- 发明人: Werngard CZECHTIZKY , John WESTON , Nils RACKELMANN , Michael PODESCHWA , Petra ARNDT , Klaus WIRTH , Heinz GOEGELEIN , Olaf RITZELER , Volker KRAFT , Patrice BELLEVERGUE , Gary MCCORT
- 申请人： Werngard CZECHTIZKY , John WESTON , Nils RACKELMANN , Michael PODESCHWA , Petra ARNDT , Klaus WIRTH , Heinz GOEGELEIN , Olaf RITZELER , Volker KRAFT , Patrice BELLEVERGUE , Gary MCCORT
- 申请人地址： FR Paris
- 专利权人： SANOFI
- 当前专利权人： SANOFI
- 当前专利权人地址： FR Paris
- 主分类号： A61K31/427
- IPC分类号： A61K31/427 ; C07D417/14 ; A61K31/497 ; A61K31/4439 ; C07F9/6539 ; A61K31/675 ; C07D487/04 ; A61K31/506 ; A61K31/444 ; C07D487/08 ; A61K31/454 ; A61P9/00 ; A61P9/12 ; A61P9/10 ; A61P13/12 ; C07D417/12
摘要：
The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
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