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发明申请
US20130079523A1 PROCESS FOR PREPARING AN INTERMEDIATE TO MU OPIOID RECEPTOR ANTAGONISTS 有权
用于制备中等程度的多种阿片受体拮抗剂的方法

PROCESS FOR PREPARING AN INTERMEDIATE TO MU OPIOID RECEPTOR ANTAGONISTS
摘要：
The invention provides an efficient method for preparing 3-endo-(8-azabicyclo[3.2.1]oct-3-yl)benzamide by hydrogenation, under controlled conditions, of an amino-protected 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)benzamide intermediate in which the amino-protecting group is removable by catalytic hydrogenation.
摘要（中）：

本发明提供了在受控条件下通过在氨基保护的3-（8-氮杂双环[3.2.1]）上氢化制备3-内 - （8-氮杂双环[3.2.1]辛-3-基）苯甲酰胺的有效方法 ]辛-2-烯-3-基）苯甲酰胺中间体，其中氨基保护基可通过催化氢化除去。

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