发明申请
US20130096160A1 ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION
审中-公开
作为生存电动神经元（SMN）蛋白质生产的调节剂的三氯化硼管理剂及相关化合物
- 专利标题： ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION
- 专利标题（中）： 作为生存电动神经元（SMN）蛋白质生产的调节剂的三氯化硼管理剂及相关化合物
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申请号： US13641383申请日： 2011-04-14
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公开(公告)号： US20130096160A1公开(公告)日： 2013-04-18
- 发明人: Juan Jose Marugan , Jingbo Xiao , Steven A. Titus , Noel Southall , Wei Zheng , Elliot J. Androphy , Jonathan Cherry
- 申请人： Juan Jose Marugan , Jingbo Xiao , Steven A. Titus , Noel Southall , Wei Zheng , Elliot J. Androphy , Jonathan Cherry
- 申请人地址： US MD Bethesda
- 专利权人： Secretary, Department of Health and Human Services,THE UNITED STATES OF AMERICA, as represented by the
- 当前专利权人： Secretary, Department of Health and Human Services,THE UNITED STATES OF AMERICA, as represented by the
- 当前专利权人地址： US MD Bethesda
- 国际申请： PCT/US11/32501 WO 20110414
- 主分类号： C07D417/04
- IPC分类号： C07D417/04
摘要：
Aryl substituted thiazol-2-yl-piperidines and related compounds useful as modulators of survival motor neuron (SMN) protein production are provided herein. Without being bound to any particular theory it is believed the aryl substituted thiazol-2-yl-piperidines and related compounds provided herein act to increase production of the SMN2 form of survival motor neuron protein. These compounds are useful for treating spinal muscular atrophy. Pharmaceutical compositions containing a carrier and one or more of the aryl substituted thiazol-2-yl-piperidine or related compounds described herein are also provided. Methods of treating spinal muscular atrophy are also provided by this disclosure.
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