发明申请
US20130123460A1 PEPTIDE FOR IMPROVING BIOSTABILITY OF BIOACTIVE SUBSTANCE, AND BIOACTIVE SUBSTANCE HAVING IMPROVED BIOSTABILITY
审中-公开
用于改善生物活性物质的生物可利用性的肽，以及具有改善的生物活性的生物活性物质
- 专利标题： PEPTIDE FOR IMPROVING BIOSTABILITY OF BIOACTIVE SUBSTANCE, AND BIOACTIVE SUBSTANCE HAVING IMPROVED BIOSTABILITY
- 专利标题（中）： 用于改善生物活性物质的生物可利用性的肽，以及具有改善的生物活性的生物活性物质
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申请号： US13636498申请日： 2011-04-28
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公开(公告)号： US20130123460A1公开(公告)日： 2013-05-16
- 发明人: Masayuki Okamoto , Ryuhji Okamoto , Tomohiro Shigemori , Takayo Murase , Atsushi Miyachi , Mitsuaki Takeuchi , Miyuki Tamura , Hiroshi Kinoshita
- 申请人： Masayuki Okamoto , Ryuhji Okamoto , Tomohiro Shigemori , Takayo Murase , Atsushi Miyachi , Mitsuaki Takeuchi , Miyuki Tamura , Hiroshi Kinoshita
- 申请人地址： JP Aichi
- 专利权人： SANWA KAGAKU KENKYUSHO CO., LTD.
- 当前专利权人： SANWA KAGAKU KENKYUSHO CO., LTD.
- 当前专利权人地址： JP Aichi
- 优先权： JP2010-105367 20100430
- 国际申请： PCT/JP2011/060446 WO 20110428
- 主分类号： C07K14/195
- IPC分类号： C07K14/195 ; C07K7/08 ; C07K7/06
摘要：
The present invention aims at providing a peptide fragment capable of improving biostability of a bioactive substance while maintaining the activity of the bioactive substance, and a bioactive substance to which the peptide fragment is added. The present invention relates to a partial peptide of a GA module having 5 to 25 amino acids, including a partial sequence of a GA module (SEQ ID NO: 1) and the amino acid sequence Ile-Asp-Glu-Ile-Leu (SEQ ID NO: 2), and a bioactive complex in which the partial peptide of the GA module is bound to a bioactive substance. The bioactive substance includes GLP-1, GLP-2, GIP, VIP, somatostatin, amylin, ghrelin, derivatives thereof, and the like.
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