发明申请
- 专利标题： NUCLEASE RESISTANT DOUBLE-STRANDED RIBONUCLEIC ACID
- 专利标题（中）： 抗核抗原双重抗坏血酸
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申请号： US13431376申请日： 2012-03-27
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公开(公告)号： US20130150570A1公开(公告)日： 2013-06-13
- 发明人: Hans-Peter VORNLOCHER , Ingo ROEHL , Philipp HADWIGER , Tracy Stage ZIMMERMANN , Muthiah MANOHARAN , Kallanthottathil G. RAJEEV , Akin AKINC
- 申请人： Hans-Peter VORNLOCHER , Ingo ROEHL , Philipp HADWIGER , Tracy Stage ZIMMERMANN , Muthiah MANOHARAN , Kallanthottathil G. RAJEEV , Akin AKINC
- 申请人地址： US MA Cambridge
- 专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C07H21/02
- IPC分类号： C07H21/02
摘要：
This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
公开/授权文献
- US08993746B2 Nuclease resistant double-stranded ribonucleic acid 公开/授权日：2015-03-31
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