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公开(公告)号：US08642076B2
公开(公告)日：2014-02-04
申请号：US13211094
申请日：2011-08-16
Applicant: Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Narayanannair K. Jayaprakash , Muthusamy Jayaraman , Martin Maier
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Narayanannair K. Jayaprakash , Muthusamy Jayaraman , Martin Maier
IPC: A61K9/48
CPC classification number: C07C219/06 , A61K9/1272 , A61K9/1273 , A61K31/325 , A61K47/34 , C07C209/78 , C07C233/36 , C07C271/10 , C07C323/25
Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
Abstract translation: 描述了用于施用基于核酸的疗法，例如缔合复合物如脂质体和脂质复合物的组合物和方法。
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公开(公告)号：US20130184326A1
公开(公告)日：2013-07-18
申请号：US13619657
申请日：2012-09-14
Applicant: Antonin de Fougerolles , Tatiana Novobrantseva , Akin Akinc
Inventor： Antonin de Fougerolles , Tatiana Novobrantseva , Akin Akinc
IPC: C12N15/113
CPC classification number: C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
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公开(公告)号：US20130035371A1
公开(公告)日：2013-02-07
申请号：US13568898
申请日：2012-08-07
Applicant: Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
Inventor： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
IPC: A61K31/713 , A61P3/06 , A61K48/00 , C12N5/071
CPC classification number: A61K31/713 , A61K9/0019 , A61K9/1272 , A61K9/1273 , A61K38/1709 , A61K47/545 , A61K47/55 , A61K47/6911 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
Abstract: This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.
Abstract translation: 本发明涉及使用针对PCSK9基因的脂质配制的siRNA的组合物和方法。
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公开(公告)号：US08334273B2
公开(公告)日：2012-12-18
申请号：US12970673
申请日：2010-12-16
Applicant: Antonin de Fougerolles , Tatiana Novobrantseva , Akin Akinc
Inventor： Antonin de Fougerolles , Tatiana Novobrantseva , Akin Akinc
CPC classification number: C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
Abstract translation: 本发明涉及用于抑制因子VII基因表达的双链核糖核酸（dsRNA）。
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公开(公告)号：US08273869B2
公开(公告)日：2012-09-25
申请号：US12816207
申请日：2010-06-15
Applicant: Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
Inventor： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
CPC classification number: A61K31/713 , A61K9/0019 , A61K9/1272 , A61K9/1273 , A61K38/1709 , A61K47/545 , A61K47/55 , A61K47/6911 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
Abstract: This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.
Abstract translation: 本发明涉及使用针对PCSK9基因的脂质配制的siRNA的组合物和方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20120016009A1
公开(公告)日：2012-01-19
申请号：US13245730
申请日：2011-09-26
Applicant: Kevin Fitzgerald , Antonin de Fougerolles , Akin Akinc , Victor E. Kotelianski
Inventor： Kevin Fitzgerald , Antonin de Fougerolles , Akin Akinc , Victor E. Kotelianski
IPC: A61K31/713 , A61P9/10 , A61P3/06
CPC classification number: C12N15/87 , A61K48/00 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2320/35 , C12N2310/3521 , C12N2310/3533
Abstract: This invention relates to optimized methods for treating diseases caused by PCSK9 gene expression.
Abstract translation: 本发明涉及治疗由PCSK9基因表达引起的疾病的优化方法。
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公开(公告)号：US20110230542A1
公开(公告)日：2011-09-22
申请号：US12554231
申请日：2009-09-04
Applicant: Pamela Tan , Birgit Bramlage , Maria Frank-Kamenetsky , Kevin Fitzgerald , Akin Akinc , Victor E. Kotelianski
Inventor： Pamela Tan , Birgit Bramlage , Maria Frank-Kamenetsky , Kevin Fitzgerald , Akin Akinc , Victor E. Kotelianski
IPC: A61K31/713 , C12N5/00 , C07H21/02 , A61P3/06
CPC classification number: C12N15/1137 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/3515 , C12N2310/3521
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK9 gene expression and the expression of the PCSK9 gene using the pharmaceutical composition; and
Abstract translation: 本发明涉及用于抑制PCSK9基因（PCSK9基因）表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸 并且其与PCSK9基因的至少一部分基本上互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 使用该药物组合物治疗由PCSK9基因表达引起的疾病和PCSK9基因表达的方法; 和
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公开(公告)号：US07928217B2
公开(公告)日：2011-04-19
申请号：US11139089
申请日：2005-05-27
Applicant: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
Inventor： Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
CPC classification number: C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/53 , C12N2320/51 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
Abstract: This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
Abstract translation: 本发明涉及在细胞和生物流体中具有改善的稳定性的修饰的双链寡核糖核酸（dsRNA），以及制备和鉴定具有改善的稳定性的dsRNA的方法，以及使用dsRNA抑制靶基因的表达或功能。
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公开(公告)号：US20110045473A1
公开(公告)日：2011-02-24
申请号：US12811511
申请日：2008-12-31
Applicant: Antonin De Fougerolles , Tatiana Novobrantseva , Anna Borodovsky , Akin Akinc , Mark Tracy
Inventor： Antonin De Fougerolles , Tatiana Novobrantseva , Anna Borodovsky , Akin Akinc , Mark Tracy
CPC classification number: G01N33/86 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12Y304/21021 , G01N2333/96447 , Y10T436/143333
Abstract: The invention features a method of identifying therapeutically relevant compositions that include a therapeutic agent and a delivery component by screening for an effect of the agent on the liver of a model subject.
Abstract translation: 本发明的特征在于通过筛选试剂对模型受试者的肝脏的影响来鉴定包括治疗剂和递送组分的治疗相关组合物的方法。
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10.发明授权公开(公告)号：US07871985B2
公开(公告)日：2011-01-18
申请号：US12331708
申请日：2008-12-10
Applicant: Antonin de Fougerolles , Tatiana Novobrantseva , Akin Akinc
Inventor： Antonin de Fougerolles , Tatiana Novobrantseva , Akin Akinc
CPC classification number: C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
Abstract translation: 本发明涉及用于抑制因子VII基因表达的双链核糖核酸（dsRNA）。
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