发明申请
US20130157945A1 PEPTIDES TARGETING TNF FAMILY RECEPTORS AND ANTAGONIZING TNF ACTION, COMPOSITIONS, METHODS AND USES THEREOF
有权
靶向TNF家族受体的拮抗剂和TNF拮抗剂的作用，组合物，方法及其用途
- 专利标题： PEPTIDES TARGETING TNF FAMILY RECEPTORS AND ANTAGONIZING TNF ACTION, COMPOSITIONS, METHODS AND USES THEREOF
- 专利标题（中）： 靶向TNF家族受体的拮抗剂和TNF拮抗剂的作用，组合物，方法及其用途
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申请号： US13739721申请日： 2013-01-11
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公开(公告)号： US20130157945A1公开(公告)日： 2013-06-20
- 发明人: Chuanju LIU
- 申请人： NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- 申请人地址： US NY New York
- 专利权人： NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- 当前专利权人： NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- 当前专利权人地址： US NY New York
- 主分类号： A61K38/18
- IPC分类号： A61K38/18 ; A61K45/06 ; C07K14/475
摘要：
The present invention provides modulators of TNF, particularly peptides and their derivatives, particularly GEP peptides, which antagonize TNF and TNF-mediated responses, activity or signaling. The invention provides methods of antagonizing TNF and the modulation of TNF-mediated diseases or responses, including inflammatory diseases and conditions. Compositions of GEP peptides, including in combination with other inflammatory mediators, are provided. Methods of treatment, alleviation, or prevention of TNF-mediated diseases and inflammatory conditions, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, inflammatory bowel diseases, Chrohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, are provided.