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1.发明授权Dendrimeric peptides, pharmaceutical compositions and methods of using the same 有权树枝状聚合肽，药物组合物及其使用方法公开(公告)号：US09079937B2
公开(公告)日：2015-07-14
申请号：US13770657
申请日：2013-02-19
CPC分类号： C07K7/02 , A61K38/10 , Y02A50/473
摘要： Novel dendrimeric peptide compounds are disclosed that have a formula represented by the following formula I: The compounds demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention and treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present peptides are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.
摘要翻译： 公开了具有由下式I表示的分子式的新颖的树状聚合肽化合物：该化合物表现出抗微生物活性并且可以制备成药物组合物并用于预防和治疗包括涉及微生物入侵的人的哺乳动物中的多种病症 。 本发明的肽特别有价值，因为它们的作用是快速的，光谱广泛的，并且对标准抗生素引发的抗性几乎无关。
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公开(公告)号：US20020037934A1
公开(公告)日：2002-03-28
申请号：US09925970
申请日：2001-08-10
发明人： Ashok Amin , Steven Abramson
IPC分类号： A61K039/395 , C12Q001/70 , A61K039/40 , A61K039/42 , A61K039/29 , C12N005/06 , C12N005/16 , A01N025/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24
摘要： Hepatitis can be treated by administering to a patient in need thereof an effective amount of a compound that neutralizes the effects of secreted TNFalpha. Two types of these compounds are extracellular ligand binding proteins of the human p75 TNF receptor, such as etanercept (Enbrel), and humanized monoclonal antibodies that neutralize the activity of TNFalpha, such as inflixamab (Remicade).
摘要翻译： 可以通过向有需要的患者施用有效量的中和分泌的TNFα的作用的化合物来治疗肝炎。 两种类型的这些化合物是人p75 TNF受体的细胞外配体结合蛋白，如依那西普（Enbrel）和中和TNFα活性的人源化单克隆抗体，如英夫利昔单抗（Remicade）。
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公开(公告)号：US10980460B2
公开(公告)日：2021-04-20
申请号：US15433117
申请日：2017-02-15
申请人： Research Foundation of The City University of New York , New York University School of Medicine
IPC分类号： A61B5/1473 , A61B5/145 , G01N33/487 , G01N33/50 , A61B5/00 , A61B5/1468 , C12Q1/6883 , A61B34/20 , A61B5/0478
摘要： The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors.
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公开(公告)号：US20170196494A1
公开(公告)日：2017-07-13
申请号：US15433117
申请日：2017-02-15
申请人： Research Foundation of The City University of New York , New York University School of Medicine
IPC分类号： A61B5/1473 , G01N33/487 , A61B34/20 , A61B5/145 , A61B5/0478 , G01N33/50 , A61B5/00
CPC分类号： A61B5/14735 , A61B5/0478 , A61B5/14507 , A61B5/14542 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/4041 , A61B5/4082 , A61B5/4094 , A61B5/4845 , A61B34/20 , A61B2562/0209 , C12Q1/6883 , G01N33/48728 , G01N33/5058 , G01N33/5091 , G01N2800/2857 , G01N2800/302
摘要： The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors.
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5.发明申请Dendrimeric Peptides, Pharmaceutical Compositions And Methods Of Using The same 有权树枝状聚合肽，药物组合物及其使用方法公开(公告)号：US20130252880A1
公开(公告)日：2013-09-26
申请号：US13770657
申请日：2013-02-19
IPC分类号： C07K7/02
CPC分类号： C07K7/02 , A61K38/10 , Y02A50/473
摘要： Novel dendrimeric peptide compounds are disclosed that have a formula represented by the following formula I: The compounds demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention and treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present peptides are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.
摘要翻译： 公开了具有由下式I表示的分子式的新颖的树状聚合肽化合物：该化合物表现出抗微生物活性并且可以制备成药物组合物并用于预防和治疗包括涉及微生物入侵的人的哺乳动物中的多种病症 。 本发明的肽特别有价值，因为它们的作用是快速的，光谱广泛的，并且对标准抗生素引发的抗性几乎无关。
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公开(公告)号：US20210074407A1
公开(公告)日：2021-03-11
申请号：US16561380
申请日：2019-09-05
发明人： Bari Dane , Thomas O'Donnell
摘要： A system and a method include acquisition of medical image data of an interval volume of a body, acquisition of camera image data of the body, the camera image data comprising an indication of diagnosis-related information, integration of the medical image data and the camera image data to generate integrated medical image data, and display of the integrated medical image data.
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公开(公告)号：US10151813B2
公开(公告)日：2018-12-11
申请号：US15196305
申请日：2016-06-29
发明人： Martijn Cloos , Lars Lauer , Daniel Sodickson , Graham Wiggins
IPC分类号： G01R33/48 , G01R33/483 , G01R33/34 , G01R33/36 , G01R33/341 , G01R33/3873 , G01R33/3875 , G01R33/561
摘要： In a magnetic resonance (MR) apparatus and a method for operation thereof, the radio-frequency (RF) resonator of the scanner of the apparatus fed from a single RF source and is operated, during a total scan duration for acquiring MR scan data from a subject, so as to excite nuclear spins in the subject with respective RF fields having different B1+ field profiles that are radiated at respectively different times during the acquisition of the scan data. The scan data acquired during the scan thus are produced from MR signals caused by nuclear spins excited by at least two different B1+ field profiles. The scan can be used to acquire MR data for MR fingerprinting.
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8.发明授权Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof 有权靶向TNF家族受体和拮抗TNF作用的肽，组合物，方法和用途公开(公告)号：US08871915B2
公开(公告)日：2014-10-28
申请号：US13739721
申请日：2013-01-11
发明人： Chuanju Liu
CPC分类号： A61K38/18 , A61K38/00 , A61K45/06 , A61K49/0008 , C07K14/475 , C07K2319/00 , G01N33/5008 , G01N2333/525 , G01N2500/10
摘要： The present invention provides modulators of TNF, particularly peptides and their derivatives, particularly GEP peptides, which antagonize TNF and TNF-mediated responses, activity or signaling. The invention provides methods of antagonizing TNF and the modulation of TNF-mediated diseases or responses, including inflammatory diseases and conditions. Compositions of GEP peptides, including in combination with other inflammatory mediators, are provided. Methods of treatment, alleviation, or prevention of TNF-mediated diseases and inflammatory conditions, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, inflammatory bowel diseases, Chrohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, are provided.
摘要翻译： 本发明提供TNF的调节剂，特别是肽及其衍生物，特别是拮抗TNF和TNF介导的应答，活性或信号传导的GEP肽。 本发明提供了拮抗TNF和调节TNF介导的疾病或反应（包括炎性疾病和病症）的方法。 提供了GEP肽的组合，包括与其它炎症介质的组合。 治疗，缓解或预防TNF介导的疾病和炎性病症的方法，包括类风湿性关节炎，骨关节炎，强直性脊柱炎，牛皮癣，炎性肠病，克罗恩病，溃疡性结肠炎，葡萄膜炎，炎症性肺病，慢性阻塞性肺疾病 提供。
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9.发明申请PEPTIDES TARGETING TNF FAMILY RECEPTORS AND ANTAGONIZING TNF ACTION, COMPOSITIONS, METHODS AND USES THEREOF 有权靶向TNF家族受体的拮抗剂和TNF拮抗剂的作用，组合物，方法及其用途公开(公告)号：US20130157945A1
公开(公告)日：2013-06-20
申请号：US13739721
申请日：2013-01-11
发明人： Chuanju LIU
IPC分类号： A61K38/18 , A61K45/06 , C07K14/475
CPC分类号： A61K38/18 , A61K38/00 , A61K45/06 , A61K49/0008 , C07K14/475 , C07K2319/00 , G01N33/5008 , G01N2333/525 , G01N2500/10
摘要： The present invention provides modulators of TNF, particularly peptides and their derivatives, particularly GEP peptides, which antagonize TNF and TNF-mediated responses, activity or signaling. The invention provides methods of antagonizing TNF and the modulation of TNF-mediated diseases or responses, including inflammatory diseases and conditions. Compositions of GEP peptides, including in combination with other inflammatory mediators, are provided. Methods of treatment, alleviation, or prevention of TNF-mediated diseases and inflammatory conditions, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, inflammatory bowel diseases, Chrohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, are provided.
摘要翻译： 本发明提供TNF的调节剂，特别是肽及其衍生物，特别是拮抗TNF和TNF介导的应答，活性或信号传导的GEP肽。 本发明提供了拮抗TNF和调节TNF介导的疾病或反应（包括炎性疾病和病症）的方法。 提供了GEP肽的组合，包括与其它炎症介质的组合。 治疗，缓解或预防TNF介导的疾病和炎性病症的方法，包括类风湿性关节炎，骨关节炎，强直性脊柱炎，牛皮癣，炎性肠病，克罗恩病，溃疡性结肠炎，葡萄膜炎，炎症性肺病，慢性阻塞性肺疾病 提供。
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