Invention Application
- Patent Title: TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS
- Patent Title (中): TRPM8拮抗剂及其在治疗中的应用
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Application No.: US13529860Application Date: 2012-06-21
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Publication No.: US20130157996A1Publication Date: 2013-06-20
- Inventor: Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
- Applicant: Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D401/14 ; C07D213/81 ; C07D487/04 ; C07D413/12 ; C07D401/12 ; C07D471/04
Abstract:
Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Public/Granted literature
- US08710043B2 TRPM8 antagonists and their use in treatments Public/Granted day:2014-04-29
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