发明申请
- 专利标题： COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST BACTERIA EXPRESSING A CARBAPENEMASE
- 专利标题（中）： 用于免疫显微镜的细菌的组合物和方法
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申请号： US13749499申请日： 2013-01-24
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公开(公告)号： US20130202616A1公开(公告)日： 2013-08-08
- 发明人: Brad J. Spellberg , Lin Lin
- 申请人： Brad J. Spellberg , Lin Lin
- 申请人地址： US CA Torrance
- 专利权人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- 当前专利权人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- 当前专利权人地址： US CA Torrance
- 主分类号： C12N9/86
- IPC分类号： C12N9/86 ; C07K16/40
摘要：
The present invention provides vaccine and pharmaceutical compositions for treating or preventing bacterial inventions. The vaccine compositions of the invention include a carbapenemase such as a serine carbapenemase, a metallo-β-lactamase or an immunogenic fragment thereof. The pharmaceutical compositions include an anti-carbapenemase antibody or fragment thereof. Also provided are methods for treating and preventing a bacterial infection using the vaccine and pharmaceutical compositions of the invention. The invention further provides antibody conjugates that include an antibody or fragment thereof conjugated to a siderophore or an analog thereof.
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