利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.025 秒)

    METHODS FOR TREATING REFRACTORY INFECTIONS IN NEUTROPENIC INDIVIDUALS
    1.
    发明申请
    METHODS FOR TREATING REFRACTORY INFECTIONS IN NEUTROPENIC INDIVIDUALS 有权
    治疗中性粒细胞性贫血感染的方法

    公开(公告)号：US20120171175A1

    公开(公告)日：2012-07-05

    申请号：US13418263

    申请日：2012-03-12

    申请人： Brad J. SPELLBERG ,  Ashraf S. IBRAHIM ,  John E Edwards, JR.

    发明人： Brad J. SPELLBERG ,  Ashraf S. IBRAHIM ,  John E Edwards, JR.

    IPC分类号： A61K35/28 ,  A61P7/00 ,  A61P31/10

    CPC分类号： C12N5/0694 ,  A61K2035/124 ,  C12N5/0642 ,  C12N2500/30 ,  C12N2500/44 ,  C12N2500/62 ,  C12N2501/385

    摘要： The invention is based, in part, on the discovery of a novel cell-based immunotherapy that can recapitulate neutrophil functions in neutropenic individuals afflicted with a microbial infection. The therapeutic methods of the invention are broadly applicable to treat any infection in a neutropenic individual, including infections caused by bacteria, fungi, protozoa, and viruses. The methods of the invention represent a practical, rapid cell-based immunotherapy for refractory infections comprising compositions of activated, irradiated HL-60 cells.

    摘要翻译： 本发明部分地基于发现一种新的基于细胞的免疫疗法，其可以概括地患有微生物感染的中性粒细胞减少的个体中的嗜中性粒细胞功能。 本发明的治疗方法广泛适用于治疗嗜中性粒细胞减少个体的任何感染，包括由细菌，真菌，原生动物和病毒引起的感染。 本发明的方法代表了用于难治性感染的实用的基于细胞的快速免疫治疗，其包含活化的照射的HL-60细胞的组合物。

    Methods for treating refractory infections in neutropenic individuals
    3.
    发明授权
    Methods for treating refractory infections in neutropenic individuals 有权
    治疗嗜中性粒细胞减少症患者难治性感染的方法

    公开(公告)号：US08790662B2

    公开(公告)日：2014-07-29

    申请号：US13418263

    申请日：2012-03-12

    申请人： Brad J. Spellberg ,  Ashraf S. Ibrahim ,  John E Edwards, Jr.

    发明人： Brad J. Spellberg ,  Ashraf S. Ibrahim ,  John E Edwards, Jr.

    IPC分类号： A61K39/00 ,  A61K39/38 ,  A01N63/00 ,  A01N65/00 ,  A01N63/04

    CPC分类号： C12N5/0694 ,  A61K2035/124 ,  C12N5/0642 ,  C12N2500/30 ,  C12N2500/44 ,  C12N2500/62 ,  C12N2501/385

    摘要： The invention is based, in part, on the discovery of a novel cell-based immunotherapy that can recapitulate neutrophil functions in neutropenic individuals afflicted with a microbial infection. The therapeutic methods of the invention are broadly applicable to treat any infection in a neutropenic individual, including infections caused by bacteria, fungi, protozoa, and viruses. The methods of the invention represent a practical, rapid cell-based immunotherapy for refractory infections comprising compositions of activated, irradiated HL-60 cells.

    摘要翻译： 本发明部分地基于发现一种新的基于细胞的免疫疗法，其可以概括地患有微生物感染的中性粒细胞减少的个体中的嗜中性粒细胞功能。 本发明的治疗方法广泛适用于治疗嗜中性粒细胞减少个体的任何感染，包括由细菌，真菌，原生动物和病毒引起的感染。 本发明的方法代表了用于难治性感染的实用的基于细胞的快速免疫治疗，其包含活化的照射的HL-60细胞的组合物。

    Compositions and methods for immunization against drug resistant Acinetobacter baumannii
    4.
    发明授权
    Compositions and methods for immunization against drug resistant Acinetobacter baumannii 失效
    免疫耐药鲍曼不动杆菌的组合物和方法

    公开(公告)号：US08747846B2

    公开(公告)日：2014-06-10

    申请号：US13470177

    申请日：2012-05-11

    申请人： Brad J. Spellberg ,  Lin Lin ,  Ashraf Ibrahim ,  Guanpingsheng Luo

    发明人： Brad J. Spellberg ,  Lin Lin ,  Ashraf Ibrahim ,  Guanpingsheng Luo

    IPC分类号： A61K39/00 ,  A61K39/395

    CPC分类号： C07K14/22 ,  A61K39/02 ,  A61K39/104 ,  A61K2039/55505 ,  C07K14/212 ,  C07K16/1203 ,  C07K16/1217 ,  C07K2317/34

    摘要： The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization against A. baumannii infection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization against A. baumannii infection. The compositions and methods of the invention are useful for preventing or treating A. baumannii infections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR) A. baumannii infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR) A. baumannii infections.

    摘要翻译： 本发明提供包含OmpA或其抗原性片段的疫苗组合物，以及针对鲍曼不动杆菌感染的主动免疫的相关方法。 本发明还提供了特异性结合OmpA的抗体及其抗原结合部分，以及针对鲍氏不动杆菌感染的相关的被动免疫方法。 本发明的组合物和方法可用于预防或治疗鲍曼不动杆菌感染，包括由对碳青霉烯类耐受的菌株和除粘菌素或替加环素之外的所有其它抗生素引起的鲍曼不动杆菌感染，也被称为极耐药（XDR）A.鲍曼不动杆菌感染， 而那些对每一个FDA批准的抗生素都有抗药性，也被称为泛耐药（PDR）A.鲍曼不动杆菌感染。

    COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST BACTERIA EXPRESSING A CARBAPENEMASE
    5.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST BACTERIA EXPRESSING A CARBAPENEMASE 有权
    用于免疫显微镜的细菌的组合物和方法

    公开(公告)号：US20130202616A1

    公开(公告)日：2013-08-08

    申请号：US13749499

    申请日：2013-01-24

    申请人： Brad J. Spellberg ,  Lin Lin

    发明人： Brad J. Spellberg ,  Lin Lin

    IPC分类号： C12N9/86 ,  C07K16/40

    CPC分类号： C12N9/86 ,  A61K2039/505 ,  C07K16/1203 ,  C07K16/40 ,  C12Y305/02006

    摘要： The present invention provides vaccine and pharmaceutical compositions for treating or preventing bacterial inventions. The vaccine compositions of the invention include a carbapenemase such as a serine carbapenemase, a metallo-β-lactamase or an immunogenic fragment thereof. The pharmaceutical compositions include an anti-carbapenemase antibody or fragment thereof. Also provided are methods for treating and preventing a bacterial infection using the vaccine and pharmaceutical compositions of the invention. The invention further provides antibody conjugates that include an antibody or fragment thereof conjugated to a siderophore or an analog thereof.

    摘要翻译： 本发明提供用于治疗或预防细菌发明的疫苗和药物组合物。 本发明的疫苗组合物包括碳青霉烯酶如丝氨酸碳青霉烯酶，金属β-内酰胺酶或其免疫原性片段。 药物组合物包括抗碳青霉烯酶抗体或其片段。 还提供了使用本发明的疫苗和药物组合物治疗和预防细菌感染的方法。 本发明还提供了抗体缀合物，其包括与铁载体或其类似物缀合的抗体或其片段。

    COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST DRUG RESISTANT ACINETOBACTER BAUMANNII
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST DRUG RESISTANT ACINETOBACTER BAUMANNII 失效
    用于免疫抗药性乙酰胆碱酯酶的组合物和方法

    公开(公告)号：US20120301474A1

    公开(公告)日：2012-11-29

    申请号：US13470177

    申请日：2012-05-11

    申请人： Brad J. Spellberg ,  Lin Lin ,  Ashraf Ibrahim ,  Guanpingsheng Luo

    发明人： Brad J. Spellberg ,  Lin Lin ,  Ashraf Ibrahim ,  Guanpingsheng Luo

    IPC分类号： A61K39/02 ,  C07K7/08 ,  C07K7/06 ,  C07K5/08 ,  A61P37/04 ,  C12N15/63 ,  C07K16/12 ,  A61K39/395 ,  A61P31/04 ,  C07K14/21 ,  C12N15/31

    CPC分类号： C07K14/22 ,  A61K39/02 ,  A61K39/104 ,  A61K2039/55505 ,  C07K14/212 ,  C07K16/1203 ,  C07K16/1217 ,  C07K2317/34

    摘要： The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization against A. baumannii infection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization against A. baumannii infection. The compositions and methods of the invention are useful for preventing or treating A. baumannii infections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR) A. baumannii infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR) A. baumannii infections.

    摘要翻译： 本发明提供包含OmpA或其抗原性片段的疫苗组合物，以及针对鲍曼不动杆菌感染的主动免疫的相关方法。 本发明还提供了特异性结合OmpA的抗体及其抗原结合部分，以及针对鲍氏不动杆菌感染的相关的被动免疫方法。 本发明的组合物和方法可用于预防或治疗鲍曼不动杆菌感染，包括由对碳青霉烯类耐受的菌株和除粘菌素或替加环素之外的所有其它抗生素引起的鲍曼不动杆菌感染，也被称为极耐药（XDR）A.鲍曼不动杆菌感染， 而那些对每一个FDA批准的抗生素都有抗药性，也被称为泛耐药（PDR）A.鲍曼不动杆菌感染。

    PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS
    9.
    发明申请
    PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 审中-公开
    药物组合物和抗肿瘤药物和其他感染性药物的方法

    公开(公告)号：US20140037689A1

    公开(公告)日：2014-02-06

    申请号：US13785835

    申请日：2013-03-05

    申请人： John E. Edwards, JR. ,  Ashraf S. Ibrahim ,  Brad J. Spellberg ,  Yue Fu ,  Scott G. Filler ,  Michael R. Yeaman

    发明人： John E. Edwards, JR. ,  Ashraf S. Ibrahim ,  Brad J. Spellberg ,  Yue Fu ,  Scott G. Filler ,  Michael R. Yeaman

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0002 ,  A61K39/085 ,  A61K2039/5156 ,  A61K2039/58 ,  C07K16/14 ,  C07K2317/76

    摘要： The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated Als protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The Als protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the Als protein family member includes Als1p, Als3p, Als5p, Als6p, Als7p or Als9p. Also provided is a method of treating or preventing Staphylococcus aureus infections.

    摘要翻译： 本发明提供了包含具有细胞粘附活性的分离的Als蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。 本发明还提供了治疗或预防血液弥漫性或粘膜皮肤念珠菌病的方法。 还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的Als蛋白家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 Als蛋白家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，Als蛋白家族成员包括Als1p，Als3p，Als5p，Als6p，Als7p或Als9p 。 还提供了治疗或预防金黄色葡萄球菌感染的方法。

    Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases
    10.
    发明授权
    Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases 有权
    疫苗组合物和治疗毛霉菌病及其他真菌病的方法

    公开(公告)号：US08444985B2

    公开(公告)日：2013-05-21

    申请号：US12661609

    申请日：2010-03-19

    申请人： Ashraf S. Ibrahim ,  Brad J. Spellberg ,  Yue Fu ,  John E. Edwards

    发明人： Ashraf S. Ibrahim ,  Brad J. Spellberg ,  Yue Fu ,  John E. Edwards

    IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K16/00

    CPC分类号： C07K16/14 ,  A61K2039/505 ,  C12N9/00 ,  C12N15/1138 ,  C12N2310/14

    摘要： The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include vaccine compositions having an FTR polypeptide or an antigenic fragment of the polypeptide; a vector including a nucleotide sequence that is substantially complimentary to at least 18 contiguous nucleotides of FTR sequence; an antisense; a small interfering RNA or an antibody inhibitor of FTR. The vaccine compositions of the invention can further include an adjuvant.

    摘要翻译： 本发明提供治疗和预防真菌病或包括毛霉菌病的病症的治疗组合物和方法。 本发明的治疗方法和组合物包括具有多肽的FTR多肽或抗原性片段的疫苗组合物; 包含与FTR序列的至少18个连续核苷酸基本互补的核苷酸序列的载体; 反义词 小干扰RNA或FTR的抗体抑制剂。 本发明的疫苗组合物还可包含佐剂。