A mute drive circuit includes a micro-controller including an I/O port; a mute circuit; and an npn transistor. When an electronic device using the mute circuit is plugged into an AC power source, the I/O port is set to the logic low, the mute circuit performs the mute mode. When the electronic device is turned on, the I/O port is controlled set to the logic low for a period and then be pulled up to the logic high, the mute circuit performs the mute mode for the period and then enters into the normal mode. When the electronic device is turned off, the I/O port is controlled to set to the logic low, the mute circuit performs the mute mode. When the electronic device is unplugged from the AC power source, the I/O port is pulled down to the logic low, the mute circuit performs the mute mode.