发明申请
US20130252944A1 NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
审中-公开
新型掺杂的吡唑衍生物及其作为代谢谷氨酸受体的独立调节剂
- 专利标题： NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
- 专利标题（中）： 新型掺杂的吡唑衍生物及其作为代谢谷氨酸受体的独立调节剂
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申请号： US13809583申请日： 2011-07-11
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公开(公告)号： US20130252944A1公开(公告)日： 2013-09-26
- 发明人: Christelle Bolea , Sylvain Celanire , Lam Tang , Philip Jones , Nigel J. Liverton , Richard Soll , Jingchao Dong , Zhiyu Lei , Fuqing Liu , Yanling Kong , Yi Ju , Haoyong Zhang , Jieping Wei , Qiaoxin Wei , Minxiang Zhang , Yunfu Luo
- 申请人： Christelle Bolea , Sylvain Celanire , Lam Tang , Philip Jones , Nigel J. Liverton , Richard Soll , Jingchao Dong , Zhiyu Lei , Fuqing Liu , Yanling Kong , Yi Ju , Haoyong Zhang , Jieping Wei , Qiaoxin Wei , Minxiang Zhang , Yunfu Luo
- 优先权： GB1011831.3 20100714
- 国际申请： PCT/US11/01206 WO 20110711
- 主分类号： C07D513/04
- IPC分类号： C07D513/04 ; A61K31/433 ; A61K31/4439 ; A61K31/506 ; C07D513/14 ; A61K45/06
摘要：
The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
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