Invention Application
- Patent Title: Method for Modifying a Property of a Protein
- Patent Title (中): 修饰蛋白质性质的方法
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Application No.: US13939291Application Date: 2013-07-11
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Publication No.: US20130316401A1Publication Date: 2013-11-28
- Inventor: Yosuke Nishio , Eiichiro Kimura , Yoshihiro Usuda , Kazuho Ikeo , Yoji Nakamura , Takashi Gojobori , Yutaka Kawarabayashi , Yumi Hino , Eiichi Hori , Jun Yamazaki
- Applicant: AJINOMOTO CO., INC.
- Applicant Address: JP Tokyo
- Assignee: AJINOMOTO CO., INC.
- Current Assignee: AJINOMOTO CO., INC.
- Current Assignee Address: JP Tokyo
- Priority: JP2002-057863 20020304
- Main IPC: C12N9/88
- IPC: C12N9/88 ; C12N9/12 ; C12N9/06

Abstract:
A method for improving the thermostability of a protein includes introducing, into the protein, two or more amino acid substitutions selected from the group consisting of: (i) substitution of an arginine residue for a lysine residue, (ii) substitution of a threonine residue for a serine residue, and (iii) substitution of an alanine residue for a serine residue.
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