发明申请
- 专利标题： PROCESS OF PRODUCING CYCLOALKYLCARBOXAMIDO-INDOLE COMPOUNDS
- 专利标题（中）： 生产环磷酰胺氧化物 - 吲哚化合物的方法
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申请号： US13642642申请日： 2011-04-21
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公开(公告)号： US20130324743A1公开(公告)日： 2013-12-05
- 发明人: Daniel T. Belmont , Cristian Harrison , Robert Michael Hughes , Young Chun Jung , Elaine Chungmin Lee , Benjamin Joseph Littler , Peter Jamison Rose , David Andrew Siesel , Gerald J. Tanoury
- 申请人： Daniel T. Belmont , Cristian Harrison , Robert Michael Hughes , Young Chun Jung , Elaine Chungmin Lee , Benjamin Joseph Littler , Peter Jamison Rose , David Andrew Siesel , Gerald J. Tanoury
- 申请人地址： US MA CAMBRIDGE
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： US MA CAMBRIDGE
- 国际申请： PCT/US2011/033396 WO 20110421
- 主分类号： C07D405/12
- IPC分类号： C07D405/12
摘要：
The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
公开/授权文献
- US09035072B2 Process of producing cycloalkylcarboxamido-indole compounds 公开/授权日：2015-05-19
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