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公开(公告)号:US20130324743A1
公开(公告)日:2013-12-05
申请号:US13642642
申请日:2011-04-21
申请人: Daniel T. Belmont , Cristian Harrison , Robert Michael Hughes , Young Chun Jung , Elaine Chungmin Lee , Benjamin Joseph Littler , Peter Jamison Rose , David Andrew Siesel , Gerald J. Tanoury
发明人: Daniel T. Belmont , Cristian Harrison , Robert Michael Hughes , Young Chun Jung , Elaine Chungmin Lee , Benjamin Joseph Littler , Peter Jamison Rose , David Andrew Siesel , Gerald J. Tanoury
IPC分类号: C07D405/12
CPC分类号: C07D317/46 , C07C209/74 , C07C225/06 , C07D209/12 , C07D317/60 , C07D405/12
摘要: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
摘要翻译: 本发明的特征在于制备化合物如(R)-1-(2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基)-N-(1-(2,3-二羟基丙基) -6-氟-2-(1-羟基-2-甲基丙-2-基)-1H-吲哚-5-基)环丙烷甲酰胺(化合物1),可用于治疗CFTR介导的疾病如囊性纤维化。
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2.SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权
标题翻译: N- [2,4-BIS(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式公开(公告)号:US20120165372A1
公开(公告)日:2012-06-28
申请号:US13413327
申请日:2012-03-06
申请人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
IPC分类号: A61K31/47 , A61P11/00 , A61P7/04 , A61P3/06 , A61P7/00 , A61P3/10 , A61P5/18 , A61P35/00 , A61P5/14 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/14 , A61P27/04 , A61P17/00 , C07D215/56
CPC分类号: C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译: 本文描述了固体形式的N- [2,4-双(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺,包括其结晶形式。
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3.Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxypheny1]-1,4-dihydro-4-oxoquinoline-3-carboxamide 有权
标题翻译: 固体形式的N- [2,4-双(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺公开(公告)号:US08163772B2
公开(公告)日:2012-04-24
申请号:US12283702
申请日:2008-09-15
申请人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
IPC分类号: C07D215/38 , A61K31/04
CPC分类号: C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译: 本文描述了固体形式的N- [2,4-双(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺,包括其结晶形式。
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4.Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 有权
标题翻译: 固体形式的N- [2,4-双(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺公开(公告)号:US20090099230A1
公开(公告)日:2009-04-16
申请号:US12283702
申请日:2008-09-15
申请人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
发明人: John DeMattei , Yushi Feng , Cristian Harrison , Adam Looker , Praveen Mudunuri , Stefanie Roeper , Yuegang Zhang
CPC分类号: C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译: 本文描述了固体形式的N- [2,4-双(1,1-二甲基乙基)-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺,包括其结晶形式。
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公开(公告)号:US09035072B2
公开(公告)日:2015-05-19
申请号:US13642642
申请日:2011-04-21
申请人: Daniel T. Belmont , Cristian Harrison , Robert Michael Hughes , Young Chun Jung , Elaine Chungmin Lee , Benjamin Joseph Littler , Peter Jamison Rose , David Andrew Siesel , Gerald J. Tanoury
发明人: Daniel T. Belmont , Cristian Harrison , Robert Michael Hughes , Young Chun Jung , Elaine Chungmin Lee , Benjamin Joseph Littler , Peter Jamison Rose , David Andrew Siesel , Gerald J. Tanoury
IPC分类号: C07D209/40 , C07D405/12 , C07D209/12 , C07D317/46 , C07D317/60
CPC分类号: C07D317/46 , C07C209/74 , C07C225/06 , C07D209/12 , C07D317/60 , C07D405/12
摘要: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
摘要翻译: 本发明的特征在于制备化合物如(R)-1-(2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基)-N-(1-(2,3-二羟基丙基) -6-氟-2-(1-羟基-2-甲基丙-2-基)-1H-吲哚-5-基)环丙烷甲酰胺(化合物1),可用于治疗CFTR介导的疾病如囊性纤维化。
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