Systems, methods, and devices for calibrating an electronic display to reduce or eliminate a mura artifact are provided. The mura artifact may be due to differential behavior of common voltage layers (VCOMs) in the electronic display. One method for reducing or eliminating the mura artifact may involve setting pixels of the electronic display to a first gray level and measuring a luminance difference between light and dark areas of a mura artifact on the electronic display. A value of an operating parameter of the electronic display may be adjusted while monitoring the luminance difference measurement. A value of the operating parameter that causes the luminance difference measurement to be within a specified range of acceptable luminance difference measurement values may be stored in the electronic display.