Invention Application
- Patent Title: Cyclic Amine Substituted Oxazolidinone CETP Inhibitor
- Patent Title (中): 环胺取代的恶唑烷酮CETP抑制剂
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Application No.: US13881896Application Date: 2011-10-25
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Publication No.: US20130331372A1Publication Date: 2013-12-12
- Inventor: Zhijian Lu , Yi-Heng Chen , Cameron Smith , Hong Li , Christopher F. Thompson , Julianne Hunt , Florida Kallashi , Ramzi Sweis , Peter Sinclair , Samantha E. Adamson , Guizhen Dong , Debra L. Ondeyka , Xiaoxia Qian , Wanying Sun , Petr Vachal , Kake Zhao
- Applicant: Zhijian Lu , Yi-Heng Chen , Cameron Smith , Hong Li , Christopher F. Thompson , Julianne Hunt , Florida Kallashi , Ramzi Sweis , Peter Sinclair , Samantha E. Adamson , Guizhen Dong , Debra L. Ondeyka , Xiaoxia Qian , Wanying Sun , Petr Vachal , Kake Zhao
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- International Application: PCT/US11/57584 WO 20111025
- Main IPC: C07D491/08
- IPC: C07D491/08 ; A61K31/5377 ; A61K31/4545 ; A61K31/444 ; A61K31/497 ; C07D417/14 ; C07D413/14 ; A61K45/06 ; A61K31/4439 ; A61K31/506
Abstract:
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substituted phenyl group or indanyl group. Formula (I).
Public/Granted literature
- US09221834B2 Cyclic amine substituted oxazolidinone CETP inhibitor Public/Granted day:2015-12-29
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