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    Monomeric and polymeric cyclic amine and-halamine compounds
    1.
    发明授权
    Monomeric and polymeric cyclic amine and-halamine compounds 失效
    单体和聚合环胺和卤胺化合物

    公开(公告)号：US5670646A

    公开(公告)日：1997-09-23

    申请号：US474302

    申请日：1995-06-07

    申请人： Shelby D. Worley ,  Gang Sun ,  Wanying Sun ,  Tay-Yuan Chen

    发明人： Shelby D. Worley ,  Gang Sun ,  Wanying Sun ,  Tay-Yuan Chen

    IPC分类号： A01N59/00 ,  C07D233/74 ,  C07D251/10 ,  C07D251/20 ,  C07D263/22 ,  C08F8/30 ,  C08F8/48 ,  C08F12/26 ,  C07D235/02

    CPC分类号： C07D233/74 ,  A01N59/00 ,  C07D251/20 ,  C08F12/26 ,  C08F8/30 ,  C08F8/48 ,  Y02W10/37

    摘要： Cyclic amine monomers and polymers and N-halamine biocidal polymer compounds are provided. Methods of making and using the same wherein the functional groups unhalogenated or halogenated hydantoins, triazine diones, imidazolidinones, and pyrimidinones are substituted onto inexpensive polymer units such as polystyrene, polyethylene, and modified polymethacrylamide are provided. The cyclic amine monomers and polymers can be utilized to form the biocidal N-halamine polymers. These N-halamine polymers are stable, insoluble biocides which release only small amounts of free halogen and other impurities. They can be useful as disinfectants for potable water, swimming pools, hot tubs, industrial water systems, cooling towers, air-conditioning systems, gas streams, paints, oils, ointments, fabrics, rubber materials, sterile bandages, coatings, hard surfaces, liners of containers, and the like.

    摘要翻译： 提供了环胺单体和聚合物以及N-卤胺杀生物聚合物化合物。 提供了制备和使用其的方法，其中将官能团的未卤化或卤代乙内酰脲，三嗪二酮，咪唑烷酮和嘧啶酮取代到廉价的聚合物单元如聚苯乙烯，聚乙烯和改性的聚甲基丙烯酰胺上。 环胺单体和聚合物可用于形成杀生物N-卤代胺聚合物。 这些N-卤代胺聚合物是仅释放少量游离卤素和其它杂质的稳定的不溶性杀生物剂。 它们可用作饮用水，游泳池，热水浴缸​​，工业水系统，冷却塔，空调系统，气体流，油漆，油，软膏，织物，橡胶材料，无菌绷带，涂层，硬表面的消毒剂， 容器内衬等。

    Monomeric and polymeric cyclic amine and N-halamine compounds
    3.
    发明授权
    Monomeric and polymeric cyclic amine and N-halamine compounds 失效
    单体和聚合环胺和N-卤代胺化合物

    公开(公告)号：US06294185B1

    公开(公告)日：2001-09-25

    申请号：US08310657

    申请日：1994-09-22

    申请人： Shelby D. Worley ,  Gang Sun ,  Wanying Sun ,  Tay-Yuan Chen

    发明人： Shelby D. Worley ,  Gang Sun ,  Wanying Sun ,  Tay-Yuan Chen

    IPC分类号： A01N2500

    CPC分类号： C07D233/74 ,  A01N59/00 ,  C07D251/20 ,  C08F8/30 ,  C08F8/48 ,  C08F12/26 ,  Y02W10/37

    摘要： Cyclic amine monomers and polymers and N-halamine biocidal polymer compounds are provided. Methods of making and using the same wherein the functional groups unhalogenated or halogenated hydantoins, triazine diones, imidazolidinones, and pyrimidinones are substituted onto inexpensive polymer units such as polystyrene, polyethylene, and modified polymethacrylamide are provided. The cyclic amine monomers and polymers can be utilized to form the biocidal N-halamine polymers. These N-halamine polymers are stable, insoluble biocides which release only small amounts of free halogen and other impurities. They can be useful as disinfectants for potable water, swimming pools, hot tubs, industrial water systems, cooling towers, air-conditioning systems, gas streams, paints, oils, ointments, fabrics, rubber materials, sterile bandages, coatings, hard surfaces, liners of containers, and the like.

    摘要翻译： 提供了环胺单体和聚合物以及N-卤胺杀生物聚合物化合物。 提供了制备和使用其的方法，其中将官能团的未卤化或卤代乙内酰脲，三嗪二酮，咪唑烷酮和嘧啶酮取代到廉价的聚合物单元如聚苯乙烯，聚乙烯和改性的聚甲基丙烯酰胺上。 环胺单体和聚合物可用于形成杀生物N-卤代胺聚合物。 这些N-卤代胺聚合物是仅释放少量游离卤素和其它杂质的稳定的不溶性杀生物剂。 它们可用作饮用水，游泳池，热水浴缸​​，工业水系统，冷却塔，空调系统，气体流，油漆，油，软膏，织物，橡胶材料，无菌绷带，涂层，硬表面的消毒剂， 容器内衬等。

    Monomeric and polymeric cyclic amine and N-halamine compounds
    4.
    发明授权
    Monomeric and polymeric cyclic amine and N-halamine compounds 失效
    单体和聚合环胺和N-卤代胺化合物

    公开(公告)号：US6020491A

    公开(公告)日：2000-02-01

    申请号：US110899

    申请日：1998-07-07

    申请人： Shelby D. Wonley ,  Gang Sun ,  Wanying Sun ,  Tay-Yuan Chen

    发明人： Shelby D. Wonley ,  Gang Sun ,  Wanying Sun ,  Tay-Yuan Chen

    IPC分类号： A01N59/00 ,  C07D233/74 ,  C07D251/10 ,  C07D251/20 ,  C07D263/22 ,  C08F8/30 ,  C08F8/48 ,  C08F12/26 ,  C07D238/10

    CPC分类号： C07D233/74 ,  A01N59/00 ,  C07D251/20 ,  C08F12/26 ,  C08F8/30 ,  C08F8/48 ,  Y02W10/37

    摘要： Cyclic amine monomers and polymers and N-halamine biocidal polymer compounds are provided. Representative monomers have the structure: ##STR1## wherein R.sup.1 is selected from the group consisting of hydrogen and from C.sub.1 to C.sub.4 alkyl; R.sup.10 is a bond or parasubstituted phenyl; and R.sup.11 is cyclic amine unit of a 5- to 6-membered heterocyclic ring selected from the group consisting of: (a) 1,3,5-triazine-2,4-dione; (b) 3,4,5,6-tetrahydro(1H)pyrimidin-2-one; and (c) 2-oxazolidinone; R.sup.10 is attached to a linkage carbon of R.sup.11, wherein said linkage carbon of R.sup.11 is a carbon located on the ring of R.sup.11 and is substituted with a substituent selected from the group consisting of C.sub.1 -C.sub.4 alkyl, benzyl, and alkyl-substituted benzyl; from 0 to 2 non-linkage carbon members are a carbonyl group; and from 0 to 1 non-linkage carbon member is substituted with a moiety selected from the group consisting of C.sub.1 -C.sub.4 alkyl, phenyl, alkyl-substituted phenyl, benzyl, alkyl-substituted benzyl, pentamethylene in spirosubstituted form and tetramethylene in spirosubstituted form. The cyclic amine monomers and polymers can be utilized to form the biocidal N-halamine polymers. These N-halamine polymers are stable, insoluble biocides which release only small amounts of free halogen and other impurities. They can be useful as disinfectants for potable water, swimming pools, hot tubs, industrial water systems, cooling towers, air-conditioning systems, gas streams, paints, oils, ointments, fabrics, rubber materials, sterile bandages, coatings, hard surfaces, liners of containers, and the like.

    摘要翻译： 提供了环胺单体和聚合物以及N-卤胺杀生物聚合物化合物。 代表性的单体具有以下结构：其中R 1选自氢和C 1至C 4烷基; R10是键或取代的苯基; 和R11是选自以下的5-至6-元杂环的环胺单元：（a）1,3,5-三嗪-2,4-二酮; （b）3,4,5,6-四氢（1H）嘧啶-2-酮; 和（c）2-恶唑烷酮; R 10连接到R 11的连接碳上，其中R 11的连接碳是位于R 11的环上的碳，并被选自C 1 -C 4烷基，苄基和烷基取代的苄基的取代基取代; 0至2个非连接碳成员为羰基; 0至1个非连接性碳成员被选自C 1 -C 4烷基，苯基，烷基取代的苯基，苄基，烷基取代的苄基，螺甲取代的五亚甲基和螺旋取代的四亚甲基中的一部分取代。 环胺单体和聚合物可用于形成杀生物N-卤代胺聚合物。 这些N-卤代胺聚合物是仅释放少量游离卤素和其它杂质的稳定的不溶性杀生物剂。 它们可用作饮用水，游泳池，热水浴缸​​，工业水系统，冷却塔，空调系统，气体流，油漆，油，软膏，织物，橡胶材料，无菌绷带，涂层，硬表面的消毒剂， 容器内衬等。

    Monomeric and polymeric cyclic amine and N-halamine compounds
    5.
    发明授权
    Monomeric and polymeric cyclic amine and N-halamine compounds 失效
    单体和聚合环胺和N-卤代胺化合物

    公开(公告)号：US5889130A

    公开(公告)日：1999-03-30

    申请号：US903861

    申请日：1997-07-31

    申请人： Shelby D. Worley ,  Gang Sun ,  Wanying Sun ,  Tay-Yuan Chen

    发明人： Shelby D. Worley ,  Gang Sun ,  Wanying Sun ,  Tay-Yuan Chen

    IPC分类号： A01N59/00 ,  C07D233/74 ,  C07D251/10 ,  C07D251/20 ,  C07D263/22 ,  C08F8/30 ,  C08F8/48 ,  C08F12/26 ,  C08F26/06 ,  C08F22/40

    CPC分类号： C07D233/74 ,  A01N59/00 ,  C07D251/20 ,  C08F12/26 ,  C08F8/30 ,  C08F8/48 ,  Y02W10/37

    摘要： Cyclic amine monomers and polymers and N-halamine biocidal polymer compounds are provided. Methods of making and using the same wherein the functional groups unhalogenated or halogenated hydantoins, triazine diones, imidazolidinones, and pyrimidinones are substituted onto inexpensive polymer units such as polystyrene, polyethylene, and modified polymethacrylamide are provided. The cyclic amine monomers and polymers can be utilized to form the biocidal N-halamine polymers. These N-halamine polymers are stable, insoluble biocides which release only small amounts of free halogen and other impurities. They can be useful as disinfectants for potable water, swimming pools, hot tubs, industrial water systems, cooling towers, air-conditioning systems, gas streams, paints, oils, ointments, fabrics, rubber materials, sterile bandages, coatings, hard surfaces, liners of containers, and the like.

    摘要翻译： 提供了环胺单体和聚合物以及N-卤胺杀生物聚合物化合物。 提供了制备和使用其的方法，其中将官能团的未卤化或卤代乙内酰脲，三嗪二酮，咪唑烷酮和嘧啶酮取代到廉价的聚合物单元如聚苯乙烯，聚乙烯和改性的聚甲基丙烯酰胺上。 环胺单体和聚合物可用于形成杀生物N-卤代胺聚合物。 这些N-卤代胺聚合物是仅释放少量游离卤素和其它杂质的稳定的不溶性杀生物剂。 它们可用作饮用水，游泳池，热水浴缸​​，工业水系统，冷却塔，空调系统，气体流，油漆，油，软膏，织物，橡胶材料，无菌绷带，涂层，硬表面的消毒剂， 容器内衬等。

    Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
    10.
    发明授权
    Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment 失效
    碳青霉烯抗菌化合物，含有这些化合物的组合物和治疗方法

    公开(公告)号：US06294529B1

    公开(公告)日：2001-09-25

    申请号：US09421690

    申请日：1999-10-07

    申请人： Lovji D. Cama ,  Ronald W. Ratcliffe ,  Robert R. Wilkening ,  Kenneth J. Wildonger ,  Wanying Sun

    发明人： Lovji D. Cama ,  Ronald W. Ratcliffe ,  Robert R. Wilkening ,  Kenneth J. Wildonger ,  Wanying Sun

    IPC分类号： C07D47714

    CPC分类号： C07D477/14

    摘要： Compounds of formula I are disclosed. as well as pharmaceutically acceptable salts thereof. The naphthosultam is substituted with various substituent groups including at least one cationic group -A-Q-L-B, wherein A-Q-L-B represents a side chain wherein: A is a C1-6 alkylene group, straight or branched, and optionally interrupted or terminated by 1-2 of —O—, —S—, NRa—, —C(O)— and —CH═CH—; Q represents  in which: b is 2 or 3; and X− is a charge balancing group; L represents a C1-8 alkylene group, unsubstituted or substituted with 1-3 Rc groups, and is interrupted or terminated by 1-3 of —CH═CH—, —C(O)—, —C(O)NRd—, —Het(Re)—, —C(O)—Het(Re)—, —C(O)NRa—Het(Re)—, —O—,—S—, —S(O)—, —SO2—, —CO2—, NRa—, —N+(Ra)2— B represents The carbapenems of the invention are effective against susceptible bacterial organisms, including methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant coagulase negative Staphylococci (MRCNS).

    摘要翻译： 公开了式I的化合物以及其药学上可接受的盐。 萘并磺胺被包括至少一个阳离子基团-AQLB的各种取代基取代，其中AQLB表示侧链，其中：A是直链或支链的C1-6亚烷基，并且任选地被1-2的-O-O - ， - S - ，NR a - ， - C（O） - 和-CH = CH-; Q表示其中：b为2或3; X为电荷平衡基团; L为C1-8亚烷基 并且被1-3个R c基团取代，并被1-3个-CH = CH-，-C（O） - ， - C（O）NR d - ， - H（Re） - ， - C（O）-Het（Re） - ， - C（O）NR a -Het（Re） - ， - O - ， - S - ， - S（O） - ， - SO 2 - ， - -N +（Ra）2-B代表本发明的碳青霉烯类对敏感细菌生物有效，包括耐甲氧西林金黄色葡萄球菌（MRSA），耐甲氧西林葡萄球菌（MRSE）和耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）。