Invention Application
- Patent Title: COMBINATORIAL THERAPY
- Patent Title (中): 组合治疗
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Application No.: US13708761Application Date: 2012-12-07
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Publication No.: US20140004038A1Publication Date: 2014-01-02
- Inventor: Anan Chuntharapai , Gregory D. Plowman , Marc Tessier-Lavigne , Yan Wu , Weilan Ye
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K45/06 ; A61K51/10
Abstract:
The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.
Public/Granted literature
- US3074378A Quick release restraining device Public/Granted day:1963-01-22
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