发明申请
- 专利标题: PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
- 专利标题(中): 制定合理统计资料的主要中间人或药物可接受的费用的程序
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申请号: US13812458申请日: 2011-07-25
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公开(公告)号: US20140051854A1公开(公告)日: 2014-02-20
- 发明人: Zdenko Casar , Damjan Sterk , Marko Jukic
- 申请人: Zdenko Casar , Damjan Sterk , Marko Jukic
- 申请人地址: SI Ljubljana
- 专利权人: LEK PHARMACEUTICALS D.D.
- 当前专利权人: LEK PHARMACEUTICALS D.D.
- 当前专利权人地址: SI Ljubljana
- 优先权: EP10170739.6 20100726
- 国际申请: PCT/EP2011/003714 WO 20110725
- 主分类号: C07D239/42
- IPC分类号: C07D239/42 ; C07C49/86 ; C07D215/14 ; C07D215/12
摘要:
The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.
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