发明申请
US20140056859A1 METHOD FOR PRODUCING MYOCARDIAL SHEET FROM EMBRYONIC STEM CELLS
有权
用于从胚胎干细胞生产心肌细胞片的方法
- 专利标题： METHOD FOR PRODUCING MYOCARDIAL SHEET FROM EMBRYONIC STEM CELLS
- 专利标题（中）： 用于从胚胎干细胞生产心肌细胞片的方法
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申请号： US14009018申请日： 2013-03-30
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公开(公告)号： US20140056859A1公开(公告)日： 2014-02-27
- 发明人: Teruo Okano , Tatsuya Shimizu , Jun Yamashita , Hidetoshi Masumoto
- 申请人： Teruo Okano , Tatsuya Shimizu , Jun Yamashita , Hidetoshi Masumoto
- 专利权人： KYOTO UNIVERSITY,TOKYO WOMAN'S MEDICAL UNIVERSITY
- 当前专利权人： KYOTO UNIVERSITY,TOKYO WOMAN'S MEDICAL UNIVERSITY
- 优先权： JP2011-076236 20110330
- 国际申请： PCT/JP2012/059427 WO 20130330
- 主分类号： A61K35/34
- IPC分类号： A61K35/34 ; A61K35/44 ; A61K9/70
摘要：
The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.
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