发明申请
US20140093912A1 METHODS OF MAKING BIOACTIVE COLLAGEN MEDICAL SCAFFOLDS SUCH AS FOR WOUND CARE DRESSINGS, HERNIA REPAIR PROSTHETICS, AND SURGICAL INCISION CLOSURE MEMBERS
有权
生产性胶原蛋白的方法如创伤性护理，HERNIA修复前列腺癌和外科手术闭塞性成员
- 专利标题： METHODS OF MAKING BIOACTIVE COLLAGEN MEDICAL SCAFFOLDS SUCH AS FOR WOUND CARE DRESSINGS, HERNIA REPAIR PROSTHETICS, AND SURGICAL INCISION CLOSURE MEMBERS
- 专利标题（中）： 生产性胶原蛋白的方法如创伤性护理，HERNIA修复前列腺癌和外科手术闭塞性成员
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申请号： US14041372申请日： 2013-09-30
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公开(公告)号： US20140093912A1公开(公告)日： 2014-04-03
- 发明人: Ali HUSSAIN , Patrick Cahalan , Linda Cahalan
- 申请人： ENSION, INC.
- 主分类号： C07K14/78
- IPC分类号： C07K14/78
摘要：
A method of preparing a crosslinked, collagen-based medical scaffold is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for wound care dressings, hernia repair prosthetics, and surgical incision closure members, prepared using the method above.