公开(公告)号：US20180064580A1

公开(公告)日：2018-03-08

申请号：US15790851

申请日：2017-10-23

申请人： Ension, Inc.

发明人： Ali HUSSAIN ,  Patrick Cahalan ,  Linda Cahalan

IPC分类号： A61F13/00 ,  C07K14/78 ,  A61L15/32 ,  A61L15/42 ,  A61L27/20 ,  A61L27/24 ,  B32B5/10 ,  A61K38/39

CPC分类号： A61F13/00012 ,  A61F13/00029 ,  A61F2013/00604 ,  A61K38/39 ,  A61L15/325 ,  A61L15/425 ,  A61L27/20 ,  A61L27/24 ,  A61L31/044 ,  A61L31/146 ,  B32B5/10 ,  B32B2250/20 ,  C07K14/78

摘要： A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.

公开(公告)号：US20140093912A1

公开(公告)日：2014-04-03

申请号：US14041372

申请日：2013-09-30

申请人： ENSION, INC.

发明人： Ali HUSSAIN ,  Patrick Cahalan ,  Linda Cahalan

IPC分类号： C07K14/78

CPC分类号： C07K14/78 ,  A61L15/325 ,  A61L15/425 ,  A61L31/044 ,  A61L31/146

摘要： A method of preparing a crosslinked, collagen-based medical scaffold is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for wound care dressings, hernia repair prosthetics, and surgical incision closure members, prepared using the method above.

摘要翻译： 提供一种制备交联的基于胶原的医用支架的方法，包括：（a）将纤维和/或非纤维胶原样品浸入缓冲的含有醇的酸性水溶液中; （b）将溶液中的胶原与包含1-乙基-3- [3-二甲基氨基丙基]碳二亚胺盐酸盐的催化组分接触至少足以在胶原上存在的氨基和羧基之间的反应并产生交联胶原， 耐脂肪酶降解; 和（c）干燥交联的胶原蛋白以产生多孔交联的胶原制品，其中多孔交联的胶原制品表现出10-500微米的孔径。 还提供了使用上述方法制备的用于伤口护理敷料，疝修补假体和外科切口闭合件的生物活性胶原蛋白医用支架。