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    Methods of making bioactive collagen wound care dressings
    1.
    发明授权
    Methods of making bioactive collagen wound care dressings 有权

    公开(公告)号：US10744039B2

    公开(公告)日：2020-08-18

    申请号：US15790851

    申请日：2017-10-23

    申请人： Ension, Inc.

    发明人： Ali Hussain ,  Patrick Cahalan ,  Linda Cahalan

    IPC分类号： A61F13/00 ,  C07K14/78 ,  A61L15/32 ,  A61L15/42 ,  A61L27/20 ,  B32B5/10 ,  A61K38/39 ,  A61L27/24 ,  A61L31/14 ,  A61L31/04

    摘要： A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.

    Adult and Pediatric Extracorporeal Life Support System with Heparin Treated Oxygenator Surface and Magnetic Levitation Motor
    2.
    发明申请
    Adult and Pediatric Extracorporeal Life Support System with Heparin Treated Oxygenator Surface and Magnetic Levitation Motor 审中-公开

    公开(公告)号：US20190125946A1

    公开(公告)日：2019-05-02

    申请号：US16220566

    申请日：2018-12-14

    申请人： Ension, Inc. ,  Massachusetts Institute of Technology

    发明人： Mark Gartner ,  Minkyun Noh ,  David L. Trumper

    IPC分类号： A61M1/10 ,  A61M1/36

    摘要： A highly portable advanced adult and pediatric compact ECLS system is based around an integrated pump-oxygenator. The system includes a central a blood inlet and flow path extending along a general longitudinal axis of the system; a pump housing defining a pump inlet in fluid communication with the central blood flow path; an impeller rotationally received within the area of the pump inlet, wherein the impeller is magnetically supported and magnetically driven; an array of hollow fiber membranes configured for gas transfer within the system for oxygenation of blood flowing across the hollow fiber membranes, wherein the membranes include a covalently-bonded heparin-based bioactive surface, and wherein the blood flow path extends from the impeller to a position to flow perpendicular over the array of hollow fiber membranes; and a blood outlet configured to receive blood flowing past the array of hollow fiber membranes.

    Methods of making bioactive collagen wound care dressings
    3.
    发明授权
    Methods of making bioactive collagen wound care dressings 有权

    公开(公告)号：US11622892B2

    公开(公告)日：2023-04-11

    申请号：US16995771

    申请日：2020-08-17

    申请人： Ension, Inc.

    发明人： Ali Hussain ,  Patrick Cahalan ,  Linda Cahalan

    IPC分类号： A61F13/00 ,  C07K14/78 ,  A61L15/32 ,  A61L15/42 ,  A61L27/20 ,  B32B5/10 ,  A61K38/39 ,  A61L27/24 ,  A61L31/14 ,  A61L31/04

    摘要： A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.

    Methods of surface treating tubular medical products
    4.
    发明授权
    Methods of surface treating tubular medical products 有权

    公开(公告)号：US10456227B2

    公开(公告)日：2019-10-29

    申请号：US15640873

    申请日：2017-07-03

    申请人： Ension, Inc.

    发明人： Ali Hussain ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner ,  Patrick Cahalan ,  Brian J Fill ,  Jeffrey W. Speakman

    IPC分类号： A61C15/04 ,  A61B17/06 ,  A61B17/064 ,  A61L31/04 ,  A61L31/10 ,  A61L33/00 ,  B05D3/06 ,  A61M1/16 ,  B05D7/02 ,  B05D1/36 ,  B05D1/00

    摘要： A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

    ENGINEERED HEPARIN BIOACTIVE MATRIX FOR CLINICAL APPLICATION OF BLOOD CONTACTING SURFACE AND METHOD OF MANUFACTURING THE SAME
    6.
    发明申请
    ENGINEERED HEPARIN BIOACTIVE MATRIX FOR CLINICAL APPLICATION OF BLOOD CONTACTING SURFACE AND METHOD OF MANUFACTURING THE SAME 有权

    公开(公告)号：US20210100935A1

    公开(公告)日：2021-04-08

    申请号：US17074888

    申请日：2020-10-20

    申请人： Ension, Inc.

    发明人： Ali Hussain ,  Linda Cahalan ,  Patrick Cahalan

    IPC分类号： A61L33/08 ,  A61L33/00

    摘要： A method of manufacturing a medical product having an engineered heparin bioactive matrix for clinical application on a blood contacting surface comprises: a) activating a blood contacting surface of at least one component of a medical device via one of plasma treatment or gas activation; b) assembling the medical product; c) Setting up medical device for wet chemistry in which wet chemistry treatments follows a blood flow path through device; d) enhancing at least the blood contacting surface with a wet chemistry treatment including an aqueous solution having a strong oxidizing agent, such as ammonium persulfate; e) adding a positively charged spacer molecule to at least the blood contacting surface with a wet chemistry treatment including an aqueous solution having a cationic polymer, such as PEI; and f) covalently immobilizing heparin to at least the blood contacting surface with a wet chemistry treatment including heparin, preferably deaminated heparin.

    METHODS OF MAKING BIOACTIVE COLLAGEN WOUND CARE DRESSINGS
    7.
    发明申请
    METHODS OF MAKING BIOACTIVE COLLAGEN WOUND CARE DRESSINGS 有权

    公开(公告)号：US20210007896A1

    公开(公告)日：2021-01-14

    申请号：US16995771

    申请日：2020-08-17

    申请人： Ension, Inc.

    发明人： Ali Hussain ,  Patrick Cahalan ,  Linda Cahalan

    IPC分类号： A61F13/00 ,  C07K14/78 ,  A61L15/32 ,  A61L15/42 ,  A61L27/20 ,  B32B5/10 ,  A61K38/39 ,  A61L27/24 ,  A61L31/14 ,  A61L31/04

    摘要： A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.

    METHODS OF MAKING BIOACTIVE COLLAGEN MEDICAL SCAFFOLDS SUCH AS FOR WOUND CARE DRESSINGS, HERNIA REPAIR PROSTHETICS, AND SURGICAL INCISION CLOSURE MEMBERS
    9.
    发明申请
    METHODS OF MAKING BIOACTIVE COLLAGEN MEDICAL SCAFFOLDS SUCH AS FOR WOUND CARE DRESSINGS, HERNIA REPAIR PROSTHETICS, AND SURGICAL INCISION CLOSURE MEMBERS 有权
    生产性胶原蛋白的方法如创伤性护理，HERNIA修复前列腺癌和外科手术闭塞性成员

    公开(公告)号：US20140093912A1

    公开(公告)日：2014-04-03

    申请号：US14041372

    申请日：2013-09-30

    申请人： ENSION, INC.

    发明人： Ali HUSSAIN ,  Patrick Cahalan ,  Linda Cahalan

    IPC分类号： C07K14/78

    CPC分类号： C07K14/78 ,  A61L15/325 ,  A61L15/425 ,  A61L31/044 ,  A61L31/146

    摘要： A method of preparing a crosslinked, collagen-based medical scaffold is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for wound care dressings, hernia repair prosthetics, and surgical incision closure members, prepared using the method above.

    摘要翻译： 提供一种制备交联的基于胶原的医用支架的方法，包括：（a）将纤维和/或非纤维胶原样品浸入缓冲的含有醇的酸性水溶液中; （b）将溶液中的胶原与包含1-乙基-3- [3-二甲基氨基丙基]碳二亚胺盐酸盐的催化组分接触至少足以在胶原上存在的氨基和羧基之间的反应并产生交联胶原， 耐脂肪酶降解; 和（c）干燥交联的胶原蛋白以产生多孔交联的胶原制品，其中多孔交联的胶原制品表现出10-500微米的孔径。 还提供了使用上述方法制备的用于伤口护理敷料，疝修补假体和外科切口闭合件的生物活性胶原蛋白医用支架。

    Method and apparatus for coupling left ventricle of the heart to the anterior interventricular vein to stimulate collateral development in ischemic regions
    10.
    发明授权
    Method and apparatus for coupling left ventricle of the heart to the anterior interventricular vein to stimulate collateral development in ischemic regions 有权

    公开(公告)号：US10512465B2

    公开(公告)日：2019-12-24

    申请号：US15450327

    申请日：2017-03-06

    申请人： Ension, Inc.

    发明人： Mark J Gartner ,  Patrick Cahalan ,  Linda Cahalan

    IPC分类号： A61B17/11 ,  A61B17/00 ,  A61F2/06 ,  A61B18/00

    摘要： An apparatus for stimulation of collateral development in ischemic cardiac regions comprises a mechanism for fluid coupling of the left ventricle of the heart to the anterior interventricular vein to stimulate collateral development in ischemic regions. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes a control of the diastolic/systolic pressure in the venous system to be within about 20-50 mmHg. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes inserting a transmyocardial conduit into the left ventricle and a tri-directional coupler attached to the anterior interventricular vein. An associated method for stimulation of collateral development in ischemic cardiac regions via the fluid coupling of the left ventricle of the heart to the anterior interventricular vein is disclosed.