发明申请
US20140113890A1 NEW 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION
有权
作为病毒复制的新型4-氨基-4-氧代戊酸酯
- 专利标题: NEW 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION
- 专利标题(中): 作为病毒复制的新型4-氨基-4-氧代戊酸酯
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申请号: US14139196申请日: 2013-12-23
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公开(公告)号: US20140113890A1公开(公告)日: 2014-04-24
- 发明人: Avinash Phadke , Dawei Chen , Venkat Gadhachanda , Akihiro Hashimoto , Godwin Pais , Xiangzhu Wang , Atul Agarwal , Ha Young Kim , Shuoming Li , Cuixian Liu , Suoming Zhang , Milind Deshpande
- 申请人: Avinash Phadke , Dawei Chen , Venkat Gadhachanda , Akihiro Hashimoto , Godwin Pais , Xiangzhu Wang , Atul Agarwal , Ha Young Kim , Shuoming Li , Cuixian Liu , Suoming Zhang , Milind Deshpande
- 申请人地址: US CT New Haven
- 专利权人: ACHILLION PHARMACEUTICALS, INC.
- 当前专利权人: ACHILLION PHARMACEUTICALS, INC.
- 当前专利权人地址: US CT New Haven
- 主分类号: C07D207/16
- IPC分类号: C07D207/16 ; C07D401/14 ; C07D413/14 ; C07D417/12 ; C07D409/14 ; C07D491/113 ; C07D487/18 ; C07D417/14 ; C07D401/12 ; C07D403/12
摘要:
The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R1, R6-R8, R16, R18, R19, M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. The 4-amino-4-oxobutanoyl peptides disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptides and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptides as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptides and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.