公开(公告)号：US08697641B2

公开(公告)日：2014-04-15

申请号：US12635049

申请日：2009-12-10

Applicant: Avinash Phadke ,  Xiangzhu Wang ,  Godwin Pais ,  Akihiro Hashimoto ,  Venkat Gadhachanda ,  Dawei Chen ,  Atul Agarwal ,  Suoming Zhang ,  Cuixian Liu ,  Shouming Li ,  Milind Deshpande

Inventor： Avinash Phadke ,  Xiangzhu Wang ,  Godwin Pais ,  Akihiro Hashimoto ,  Venkat Gadhachanda ,  Dawei Chen ,  Atul Agarwal ,  Suoming Zhang ,  Cuixian Liu ,  Shouming Li ,  Milind Deshpande

IPC: A01N37/18

Abstract: The invention provides 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Formula I and the pharmaceutically salts thereof. The variables are defined herein. Certain compounds of Formula I are useful as antiviral agents. 4-amino-4-oxobutanoyl peptide cyclic analogues as disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptide cyclic analogues and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptide cyclic analogue as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptide cyclic analogue and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in patients.

公开(公告)号：US08409366B2

公开(公告)日：2013-04-02

申请号：US12801716

申请日：2010-06-22

Applicant: Mitsuhiko Ogihara ,  Tomohiko Sagimori ,  Masaaki Sakuta ,  Akihiro Hashimoto

Inventor： Mitsuhiko Ogihara ,  Tomohiko Sagimori ,  Masaaki Sakuta ,  Akihiro Hashimoto

IPC: H01L29/16 ,  H01L33/00 ,  H01L21/02 ,  H01L29/20

CPC classification number: H01L33/007 ,  H01L21/02378 ,  H01L21/02444 ,  H01L21/0254 ,  H01L21/02612 ,  H01L21/0262 ,  H01L21/02631 ,  H01L21/02664 ,  H01L29/16 ,  H01L29/1606 ,  H01L29/2003 ,  H01L33/0079

Abstract: In a separation method of a nitride semiconductor layer, a graphene layer in the form of a single layer or two or more layers is formed on a surface of a first substrate. A nitride semiconductor layer is formed on the graphene layer so that the nitride semiconductor layer is bonded to the graphene layer with a bonding force due to regularity of potential at atomic level at an interface therebetween without utilizing covalent bonding. The nitride semiconductor layer is separated from the first substrate with a force which is greater than the bonding force between the nitride semiconductor layer and the graphene layer, or greater than a bonding force between respective layers of the graphene layer.

Abstract translation: 在氮化物半导体层的分离方法中，在第一衬底的表面上形成单层或两层以上形式的石墨烯层。 在石墨烯层上形成氮化物半导体层，使得氮化物半导体层由于在它们之间的界面处的原子水平的电位的规则性而具有结合力而与石墨烯层结合，而不使用共价键。 氮化物半导体层以比氮化物半导体层和石墨烯层之间的结合力大的力或者大于石墨烯层的各层之间的结合力与第一基板分离。

公开(公告)号：US08114888B2

公开(公告)日：2012-02-14

申请号：US11354521

申请日：2006-02-15

Applicant: Barton James Bradbury ,  Godwin Pais ,  Qiuping Wang ,  Milind Deshpande ,  Michael Pucci ,  Yongsheng Song ,  Edlaine Lucien ,  Jason Allan Wiles ,  Akihiro Hashimoto

Inventor： Barton James Bradbury ,  Godwin Pais ,  Qiuping Wang ,  Milind Deshpande ,  Michael Pucci ,  Yongsheng Song ,  Edlaine Lucien ,  Jason Allan Wiles ,  Akihiro Hashimoto

IPC: A61K31/4365 ,  A61K31/4375 ,  C07D491/14

CPC classification number: C07D513/04 ,  C07D513/14

Abstract: The invention provides certain compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein.

Abstract translation: 本发明提供某些具有抗微生物活性的式I和式II化合物和盐。 本发明还提供了可用于制备式I和式II化合物的新型合成中间体。 变量A1，R2，R3，R5，R6，R7，A8和R9在本文中定义。

公开(公告)号：US20110154650A1

公开(公告)日：2011-06-30

申请号：US12966084

申请日：2010-12-13

Applicant: Akihiro Hashimoto

Inventor： Akihiro Hashimoto

IPC: H02K15/02

CPC classification number: H02K15/022 ,  H02K1/146 ,  Y10T29/49009 ,  Y10T29/49012 ,  Y10T29/49078 ,  Y10T29/5137 ,  Y10T29/53143

Abstract: A method for manufacturing a laminated core, comprising: (1) blanking a rotor core sheet 15 and a stator core sheet 14 from a thin strip material 27, the stator core sheet 14 positioned so as to have a common axis with the rotor core sheet 15, and including a ring-shaped yoke piece 18 and plural magnetic pole pieces 19 integrally connecting to a radially inside of the yoke piece 18, each of the magnetic pole pieces 19 including a magnetic pole shaft piece 20 and a magnetic pole tooth piece 21; and (2) laminating the stator core sheet 14 inside a die; wherein to form the magnetic pole pieces 19, firstly preparatory slots 29, smaller than finishing slots 30, are blanked, the adjacent finishing slots 30 forming each of the magnetic pole pieces 19; secondly a part or a whole of the magnetic pole shaft pieces 20 each are coined to elongate the same in a radially inward direction; and thereafter the finishing slots 30 are blanked and the magnetic pole tooth pieces 21 are shaped. This enables the elongation of the magnetic pole piece 19, improving caulking and dimensional accuracies of the laminated core when both of the core sheets 14, 15 are produced from one thin strip material 27.

Abstract translation: 一种叠层铁心的制造方法，其特征在于，包括：（1）从薄带状材料27冲切转子铁芯片15和定子铁芯片14，定子铁心片14与转子铁心片 如图15所示，包括环形轭片18和与轭片18的径向内侧整体连接的多个磁极片19，每个磁极片19包括磁极轴件20和磁极齿片21 ; 和（2）将定子铁芯片14层压在模具内; 其中，为了形成磁极片19，首先将预制槽29小于精加工槽30，冲切相邻的精加工槽30，形成每个磁极片19; 其次，磁极轴件20的一部分或全部各自被制造成在径向向内的方向上延伸; 然后将精加工槽30冲切，并使磁极齿片21成形。 这样，当两个芯片14,15由一个薄条带材料27制成时，这使得磁极片19的伸长率提高了叠层芯的铆接和尺寸精度。

公开(公告)号：US20100318258A1

公开(公告)日：2010-12-16

申请号：US11993006

申请日：2006-06-29

Applicant: Tsuyoshi Katayama ,  Akihiro Hashimoto ,  Hiroji Kohsaka ,  Masatomo Ishikura

Inventor： Tsuyoshi Katayama ,  Akihiro Hashimoto ,  Hiroji Kohsaka ,  Masatomo Ishikura

IPC: G06F7/00

CPC classification number: G07C5/0858 ,  G07C5/008 ,  G07C5/0891

Abstract: This invention intends to provide a vehicle-mounted driving recorder that can facilitate an after-the-fact analysis on not only situation data at a time of an accident but also situation data at a time of a hiyari-hatto and that can contribute accident prevention. The vehicle-mounted driving recorder comprises a data receiving section that receives situation data indicating behavior, a surrounding situation, and an operating situation of a vehicle and a data administration section that classifies the situation data into one of predetermined multiple categories based on contents of the received situation data and stores the classified situation data in a situation data storage section specified in a predetermined area of a memory.

Abstract translation: 本发明旨在提供一种车载驾驶记录仪，其可以便于在事故时不仅情况数据的事后分析，而且可以有助于事故分析，并且还可以有助于事故预防 。 车载驾驶记录仪包括：数据接收部，其接收表示车辆的状况数据，周围情况和运行状况;以及数据管理部，其基于所述情况数据的内容将所述情况数据分类为预定的多个类别 接收到的情况数据，并将分类情况数据存储在在存储器的预定区域中指定的情况数据存储部分中。

公开(公告)号：US20100152103A1

公开(公告)日：2010-06-17

申请号：US12635049

申请日：2009-12-10

Applicant: Avinash Phadke ,  Xiangzhu Wang ,  Godwin Pais ,  Akihiro Hashimoto ,  Venkat Gadhachanda ,  Dawei Chen ,  Atul Agarwal ,  Suoming Zhang ,  Cuixian Liu ,  Shouming Li ,  Milind Deshpande

Inventor： Avinash Phadke ,  Xiangzhu Wang ,  Godwin Pais ,  Akihiro Hashimoto ,  Venkat Gadhachanda ,  Dawei Chen ,  Atul Agarwal ,  Suoming Zhang ,  Cuixian Liu ,  Shouming Li ,  Milind Deshpande

IPC: A61K38/12 ,  C07K5/12 ,  A61P31/12

CPC classification number: C07K5/12 ,  A61K38/00 ,  C07K5/06165

Abstract: The invention provides 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Formula I and the pharmaceutically salts thereof.The variables are defined herein. Certain compounds of Formula I are useful as antiviral agents. 4-amino-4-oxobutanoyl peptide cyclic analogues as disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptide cyclic analogues and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptide cyclic analogue as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptide cyclic analogue and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in patients.

Abstract translation: 本发明提供了式I的4-氨基-4-氧代丁酰基肽及其环状类似物及其药学上可接受的盐。 变量在此定义。 某些式I化合物可用作抗病毒剂。 本文公开的4-氨基-4-氧代丁酰基肽环类似物是病毒复制，特别是丙型肝炎病毒复制的有效和/或选择性抑制剂。 本发明还提供含有一种或多种4-氨基-4-氧代丁酰基肽环状类似物和一种或多种药学上可接受的载体的药物组合物。 这样的药物组合物可以含有4-氨基-4-氧代丁酰基肽环类似物作为唯一的活性剂，或者可以含有4-氨基-4-氧代丁酰基肽环类似物和一种或多种其它药物活性剂的组合。 本发明还提供了用于治疗患者中的病毒感染（包括丙型肝炎感染）的方法。

公开(公告)号：US20060173026A1

公开(公告)日：2006-08-03

申请号：US11345201

申请日：2006-02-01

Applicant: Barton Bradbury ,  Jason Wiles ,  Milind Deshpande ,  Quiping Wang ,  Akihiro Hashimoto ,  Edlaine Lucien

Inventor： Barton Bradbury ,  Jason Wiles ,  Milind Deshpande ,  Quiping Wang ,  Akihiro Hashimoto ,  Edlaine Lucien

IPC: A61K31/519 ,  A61K31/4745 ,  C07D491/14

CPC classification number: C07D513/14 ,  C07D498/14 ,  C07D513/22 ,  C07D519/00

Abstract: The invention provides compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A1, A8, R2, R3, R5, R6, R7, and R9 are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of compounds of Formula I and/or Formula II and one or more other active agents. The invention also provides methods for treating microbial and protozoal infections in animals.

Abstract translation: 本发明提供具有抗微生物活性的式I和式II化合物和盐。 本发明还提供了可用于制备式I和式II化合物的新型合成中间体。 变量A 1，A 8，R 2，R 3，R 5，/ 3 >，R 6，R 7和R 9在本文中定义。 本文公开的某些式I和式II化合物是细菌DNA合成和细菌复制的有效和选择性抑制剂。 本发明还提供包含一种或多种式I或式II化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。 这样的组合物可以含有式I或式II的化合物作为唯一的活性剂或可以含有式I和/或式II化合物与一种或多种其它活性剂的组合。 本发明还提供了用于处理动物中的微生物和原生动物感染的方法。

公开(公告)号：US07031087B2

公开(公告)日：2006-04-18

申请号：US10428127

申请日：2003-05-02

Applicant: Akihiro Hashimoto

Inventor： Akihiro Hashimoto

IPC: G11B5/09 ,  G11B21/02

CPC classification number: G11B5/584

Abstract: Object of this invention is to provide a servo writer capable of automatically controlling record current amount supplied to a writing head for every kind of magnetic tape when writing a servo signal on many kinds of magnetic tapes. The servo writer for writing a servo signal on magnetic tape MT which is fed out from a feeding reel and taken-up by a take-up reel includes writing head H1 that writes a servo signal on the magnetic tape MT, inspection head H2 for reading the servo signal formed on the downstream side and written on the magnetic tape MT, servo signal inspection part 16 that inspects the servo signal read by the inspection head H2, and current amount control part 17 that controls the amount of record current supplied to the writing head H1 based on the inspection result in the servo signal inspection part 16.

Abstract translation: 本发明的目的在于提供一种在多种磁带上写入伺服信号时能够自动控制提供给每种磁带的写入头的记录电流量的伺服写入器。 伺服写入器将伺服信号写入磁带MT，该磁带MT从馈送卷轴送出并被卷取卷轴卷绕，包括将伺服信号写入磁带MT的写入头H 1，检查头H 2 用于读取形成在下游侧并写入磁带MT的伺服信号，检查由检查头H 2读取的伺服信号的伺服信号检测部分16以及控制提供的记录电流量的电流量控制部分17 基于伺服信号检查部16的检查结果，写入写入头H 1。

公开(公告)号：US20060004723A1

公开(公告)日：2006-01-05

申请号：US11138315

申请日：2005-05-27

Applicant: Akihito Fujiwara ,  Seiji Nakano ,  Masakazu Takahashi ,  Hiroyuki Akama ,  Kazunori Saitoh ,  Kazushige Kawana ,  Akihiro Hashimoto

Inventor： Akihito Fujiwara ,  Seiji Nakano ,  Masakazu Takahashi ,  Hiroyuki Akama ,  Kazunori Saitoh ,  Kazushige Kawana ,  Akihiro Hashimoto

IPC: G06F17/30

CPC classification number: H04N21/435 ,  G06F16/68 ,  G10L19/167 ,  H04N21/235 ,  H04N21/439 ,  H04N21/44 ,  H04N21/8173 ,  H04N21/8405

Abstract: A method for reading tag data is provided, involving reading a compressed data file that includes compressed data and tag data of a fixed length appended to the compressed data at a predetermined position, and performing a predetermined process based on the type of the compressed data. The reading process of the compressed data file includes first searching for the starting position of the tag data of the compressed data file and retrieving the tag data, followed by searching for the starting position of the compressed data.

Abstract translation: 提供了一种用于读取标签数据的方法，涉及在预定位置读取包含附加到压缩数据的固定长度的压缩数据和标签数据的压缩数据文件，并且基于压缩数据的类型执行预定处理。 压缩数据文件的读取处理包括首先搜索压缩数据文件的标签数据的起始位置并检索标签数据，然后搜索压缩数据的起始位置。

公开(公告)号：US20050152065A1

公开(公告)日：2005-07-14

申请号：US10990369

申请日：2004-11-18

Applicant: Akihiro Hashimoto ,  Takahisa Izumida

Inventor： Akihiro Hashimoto ,  Takahisa Izumida

IPC: G11B15/60 ,  G11B5/55 ,  G11B15/62

CPC classification number: G11B15/60 ,  G11B15/62

Abstract: Disclosed is a magnetic tape transport system which has multiple magnetic heads arranged parallel to each other that a magnetic tape slides in contact with, and which has a structure to prevent a decrease in contact pressure between the magnetic tape and the magnetic heads. The magnetic tape transport system includes a supply reel for feeding the magnetic tape, a take-up reel for winding the magnetic tape fed from the supply reel, a plurality of magnetic heads being arranged parallel to each other, a partition plate for dividing a space between the magnetic heads into an air space and a close-tape space, a negative pressure generation means for setting a pressure in the air space to be lower than that in the close-tape space, and a communicating path for allowing the air space and the close-tape space to communicate with each other.

Abstract translation: 公开了一种磁带传送系统，其具有彼此平行布置的多个磁头，磁带与磁盘滑动接触，并且具有防止磁带和磁头之间的接触压力降低的结构。 磁带传送系统包括用于馈送磁带的供带盘，用于卷绕从供带盘馈送的磁带的卷取卷轴，彼此平行布置的多个磁头，用于分隔空间的分隔板 在磁头之间形成空气空间和封闭空间的负压产生装置，用于将空气空间中的压力设定为低于靠近磁带空间的负压产生装置，以及用于允许空气空间和 相邻的磁带空间进行通信。