发明申请
US20140155377A1 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS
审中-公开
作为化合物受体的调节剂的3-环丙基甲基吡咯烷酮衍生物
- 专利标题： 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS
- 专利标题（中）： 作为化合物受体的调节剂的3-环丙基甲基吡咯烷酮衍生物
-
申请号： US14174300申请日： 2014-02-06
-
公开(公告)号： US20140155377A1公开(公告)日： 2014-06-05
- 发明人: Chu-Biao Xue , Brian W. Metcalf , Amy Qi Han , Darius J. Robinson , Changsheng Zheng , Anlai Wang , Yingxin Zhang
- 申请人： Chu-Biao Xue , Brian W. Metcalf , Amy Qi Han , Darius J. Robinson , Changsheng Zheng , Anlai Wang , Yingxin Zhang
- 申请人地址： US DE Wilmington
- 专利权人： Incyte Corporation
- 当前专利权人： Incyte Corporation
- 当前专利权人地址： US DE Wilmington
- 主分类号： C07D207/14
- IPC分类号： C07D207/14 ; C07D417/12 ; C07D413/14 ; C07D403/12 ; C07D401/14 ; C07D413/12 ; C07D401/12 ; C07D417/14
摘要：
The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
信息查询
